Diagnosis and Management of Gastroesophageal Reflux Disease in Infants and Children: from Guidelines to Clinical Practice

다국어 초록 (Multilingual Abstract)

The diagnosis and management of gastro-esophageal reflux (GER) and GER disease (GERD) in infants and children remains a challenge. Published guidelines and position papers, along with Embase, MEDLINE, and the Cochrane Database were reviewed and summarized with the intent to propose a practical approach and management of GER and GERD for healthcare providers and to standardize and improve the quality of care for infants and children. For this purpose, 2 algorithms were developed, 1 for infants <12 months of age and the other for older children. None of the signs and symptoms of GER and GERD are specific and there is no gold standard diagnostic test or tool. Nutritional management is recommended as a first-line approach in infants, while in children, a therapeutic trial with antacid medication is advised for early management. The practical recommendations from this review are intended to optimize the management of GER in infants and older children and reduce the number of investigations and inappropriate use of medication.

참고문헌 (Reference)

1 Euler AR, "Use of bethanechol for the treatment of gastroesophageal reflux" 96 : 321-324, 1980

2 Westra SJ, "Ultrasound diagnosis of gastroesophageal reflux and hiatal hernia in infants and young children" 18 : 477-485, 1990

3 Rao NM, "Two years' experience of using the Bravo wireless oesophageal pH monitoring system at a single UK tertiary centre" 106 : 312-315, 2017

4 Rothenberg SS, "Two decades of experience with laparoscopic nissen fundoplication in infants and children : a critical evaluation of indications, technique, and results" 23 : 791-794, 2013

5 Salvatore S, "Thickened infant formula : what to know" 49 : 51-56, 2018

6 Yadlapati R, "The"dangers"of chronic proton pump inhibitor use" 141 : 79-81, 2018

7 O'Reilly RC, "The role of extraesophageal reflux in otitis media in infants and children" 118 (118): 1-9, 2008

8 Rosen R, "The presence of pepsin in the lung and its relationship to pathologic gastro-esophageal reflux" 24 : 129-133, 2012

9 Li S, "The effects of baclofen for the treatment of gastroesophageal reflux disease : a meta-analysis of randomized controlled trials" 2014 : 307805-, 2014

10 Salvatore S, "The effect of alginate in gastroesophageal reflux in infants" 20 : 575-583, 2018

11 Lau Moon Lin M, "The Safety of metoclopramide in children : a systematic review and meta-analysis" 39 : 675-687, 2016

12 Dy F, "Salivary pepsin lacks sensitivity as a diagnostic tool to evaluate extraesophageal reflux disease" 177 : 53-58, 2016

13 Moon RY, "SIDS and other sleep-related infant deaths: expansion of recommendations for a safe infant sleeping environment" 128 : 1030-1039, 2011

14 Tucker E, "Rumination variations : aetiology and classification of abnormal behavioural responses to digestive symptoms based on high-resolution manometry studies" 37 : 263-274, 2013

15 Dalla Vecchia LK, "Reoperation after Nissen fundoplication in children with gastroesophageal reflux : experience with 130 patients" 226 : 315-321, 1997

16 Ravelli AM, "Pulmonary aspiration shown by scintigraphy in gastroesophageal reflux-related respiratory disease" 130 : 1520-1526, 2006

17 Kelly EA, "Prevalence of pediatric aspiration-associated extraesophageal reflux disease" 139 : 996-1001, 2013

18 Martigne L, "Prevalence and management of gastroesophageal reflux disease in children and adolescents : a nationwide cross-sectional observational study" 171 : 1767-1773, 2012

19 Gupta SK, "Presenting symptoms of nonerosive and erosive esophagitis in pediatric patients" 51 : 858-863, 2006

20 Schneider A, "Postoperative lower esophageal dilation in children following the performance of Nissen fundoplication" 22 : 399-403, 2012

21 Fortunato JE, "Pepsin in saliva as a biomarker for oropharyngeal reflux compared with 24-hour esophageal impedance/pH monitoring in pediatric patients" 29 : e12936-, 2017

22 Farrell S, "Pepsin in bronchoalveolar lavage fluid : a specific and sensitive method of diagnosing gastro-oesophageal reflux-related pulmonary aspiration" 41 : 289-293, 2006

23 Vandenplas Y, "Pediatric gastroesophageal reflux clinical practice guidelines: joint recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN)" 49 : 498-547, 2009

24 Rosen R, "Pediatric gastroesophageal reflux clinical practice guidelines : joint recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition" 66 : 516-554, 2018

25 Kessing BF, "Objective manometric criteria for the rumination syndrome" 109 : 52-59, 2014

26 Orenstein SR, "Multicenter, double-blind, randomized, placebo-controlled trial assessing the efficacy and safety of proton pump inhibitor lansoprazole in infants with symptoms of gastroesophageal reflux disease" 154 : 514-520.e4, 2009

27 Rosen R, "Lipid-laden macrophage index is not an indicator of gastroesophageal reflux-related respiratory disease in children" 121 : e879-84, 2008

28 Pashankar DS, "Increased prevalence of gastroesophageal reflux symptoms in obese children evaluated in an academic medical center" 43 : 410-413, 2009

29 Cucchiara S, "Histologic grading of reflux oesophagitis and its relationship with intra-oesophageal and intragastric pH variables" 5 : 621-626, 1993

30 Katz PO, "Guidelines for the diagnosis and management of gastroesophageal reflux disease" 108 : 308-328, 2013

31 Arasu TS, "Gastroesophageal reflux in infants and children comparative accuracy of diagnostic methods" 96 : 798-803, 1980

32 Davies I, "Gastro-oesophageal reflux disease in children: NICE guidance" 350 : g7703-, 2015

33 Koebnick C, "Extreme childhood obesity is associated with increased risk for gastroesophageal reflux disease in a large population-based study" 6 : e257-63, 2011

34 Cabrera J, "Esophageal pH monitoring with the BRAVO capsule: experience in a single tertiary medical center" 53 : 404-408, 2011

35 van der Pol RJ, "Efficacy of proton-pump inhibitors in children with gastroesophageal reflux disease : a systematic review" 127 : 925-935, 2011

36 Tolia V, "Efficacy of lansoprazole in the treatment of gastroesophageal reflux disease in children" 35 (35): S308-318, 2002

37 Haddad I, "Efficacy and safety of rabeprazole in children(1–11 years)with gastroesophageal reflux disease" 57 : 798-807, 2013

38 Fiedorek S, "Efficacy and safety of lansoprazole in adolescents with symptomatic erosive and non-erosive gastroesophageal reflux disease" 40 : 319-327, 2005

39 Ummarino D, "Effect of magnesium alginate plus simethicone on gastroesophageal reflux in infants" 60 : 230-235, 2015

40 Omari TI, "Effect of baclofen on esophagogastric motility and gastroesophageal reflux in children with gastroesophageal reflux disease : a randomized controlled trial" 149 : 468-474, 2006

41 Rohof WO, "Effect of azithromycin on acid reflux, hiatus hernia and proximal acid pocket in the postprandial period" 61 : 1670-1677, 2012

42 Morris AD, "Domperidone-associated QT interval prolongation in non-oncologic pediatric patients : a review of the literature" 69 : 224-230, 2016

43 Carroccio A, "Domperidone plus magnesium hydroxide and aluminum hydroxide: a valid therapy in children with gastroesophageal reflux. A double-blind randomized study versus placebo" 29 : 300-304, 1994

44 De Loore I, "Domperidone drops in the symptomatic treatment of chronic paediatric vomiting and regurgitation. A comparison with metoclopramide" 55 (55): 40-42, 1979

45 Ravelli AM, "Dilated intercellular spaces : a major morphological feature of esophagitis" 42 : 510-515, 2006

46 Patra S, "Diagnostic modalities for gastro-esophageal reflux in infantile wheezers" 57 : 99-103, 2011

47 Trikha A, "Development of food allergies in patients with gastroesophageal reflux disease treated with gastric acid suppressive medications" 24 : 582-588, 2013

48 Farhath S, "Detection of pepsin in mouth swab : correlation with clinical gastroesophageal reflux in preterm infants" 26 : 819-824, 2013

49 Jang HS, "Correlation of color Doppler sonographic findings with pH measurements in gastroesophageal reflux in children" 29 : 212-217, 2001

50 Miller S, "Comparison of the efficacy and safety of a new aluminium-free paediatric alginate preparation and placebo in infants with recurrent gastro-oesophageal reflux" 15 : 160-168, 1999

51 Baker R, "Clinical results from a randomized, double-blind, dose-ranging study of pantoprazole in children aged 1 through 5 years with symptomatic histologic or erosive esophagitis" 49 : 852-865, 2010

52 Khoshoo V, "Clinical response to 2 dosing regimens of lansoprazole in infants with gastroesophageal reflux" 46 : 352-354, 2008

53 Hyman PE, "Childhood functional gastrointestinal disorders : neonate/toddler" 130 : 1519-1526, 2006

54 Rasquin A, "Childhood functional gastrointestinal disorders : child/adolescent" 130 : 1527-1537, 2006

55 Rosen R, "Changes in gastric and lung microflora with acid suppression : acid suppression and bacterial growth" 168 : 932-937, 2014

56 Levi P, "Bethanechol versus antiacids in the treatment of gastroesophageal reflux" 40 : 349-359, 1985

57 Krishnan U, "Assay of tracheal pepsin as a marker of reflux aspiration" 35 : 303-308, 2002

58 Vandenplas Y, "Area under pH 4 : advantages of a new parameter in the interpretation of esophageal pH monitoring data in infants" 9 : 34-39, 1989

59 Croffie JM, "Accuracy and tolerability of the Bravo catheter-free pH capsule in patients between the ages of 4 and 18 years" 45 : 559-563, 2007

60 Hambraeus M, "A literature review of the outcomes after robot-assisted laparoscopic and conventional laparoscopic Nissen fundoplication for gastro-esophageal reflux disease in children" 9 : 428-432, 2013