궤양성 대장염의 Antineutrophil Cytoplasmic Antibody ( ANCA ) 발현율 = Antineutrophil Cytoplasmic Antibody (ANCA) of Ulcerative Colitis in Korea궤양성 대장염의 Antineutrophil Cytoplasmic Antibody ( ANCA ) 발현율

다국어 초록 (Multilingual Abstract)

Antineutrophil cytoplasmic antibodies (ANCA) are autoantibodies against various antigens present in the cytoplasmic primary granules of neutrophils detected by standard indirect immunofluorescent technique fixing the neutrophil with alcohol. There are two types of ANCA characterized by immunoreactivity, perinuclear type AACA(P-ANCA) and cytoplasmic type ANCA(C-ANCA). ANCA was demonstrated in the sera of patients with inflammatory bowel disease. We have evaluated the reactivity against human neutrophils of sera from 44 patients with ulcerative colitis, 4 Crohns disease, 3 tuberculous colitis, 2 Behqets disease, 10 simple co- litis and 25 healthy controls. 26/44 (59.1%) sera from patients with ulcerative colitis con- tained ANCA compared with 2/4 (50.0%) from Crohns disease, 1/2 (50.0%) from Behqets disease and 2/25 (8%) from control sera. All ten from patients with simple colitis and all three sera from tuberculous colitis were negative. The presence or titer of ANCA was not cor- related with activity of treatment of ulcerative colitis. The predominant pattern of ANCA was cytoplasmic (30/31) and only one serum gave a perinucleatr pattern. In conclusion, ANCA occurred more commonly in ulcerative colitis than tuberculous colitis or simple colitis.(Korean J Gastroenterol 1994;26: 451 457)