단백질 용액을 흡착시킨 고분자 표면상의 혈소판 상호작용에 관한 연구 = Platelet interaction with various polymeric substrates after proteins adsorption

다국어 초록 (Multilingual Abstract)

Platelet adhesion onto various polymeric materials after protein adsorption has been tested in vitro by employing short-term measuring equipment such as in situ epifluorescence video microscopy. The adsorption of fibrinogen from 1% dilute plasma was performed on the surfaces of poly(urethane) derivatives films such as Biomer, poly(ether urethane urea), poly(ether urethane), silicone urethane copolymer silicone rubber and poly(ether urethane) derived with the anti-calcifying agent hydroxyethane bisphosphate. The polymer surfaces pre-adsorbed with fibrinogen were exposed in vitro to the heparinized human whole blood for the initial interactions of platelets and polymorphonuclear leuckocytes for 5 to 10 min. Dependence of finbrinogen pre-adsorption on the platelets adhesion onto the polymeric surfaces was evident from the measurement of adhered platelets and leuckocytes coverage area, i.e. the fibrinogen adsorbed polymers showed more cell coverage by cellular adhesion and spread than the control untreated polymers did. These results indicate that the adsorption of cell adhesion-inducing proteins is important for the designs of blood-contacting materials.

목차 (Table of Contents)

• 1.서론
• 2.실험방법
• 3.실험결과와 고찰
• 4.결론