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    Dapagliflozin을 복용 중인 제2형 당뇨병 환자에서 황련해독탕 병용투여의 약력학적 약물상호작용 평가 = Pharmacodynamic Herb-drug Interaction between Hwangryunhaedok-tang and Dapagliflozin in Type 2 Diabetes Melitus

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    https://www.riss.kr/link?id=A109969204

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    Objective: This study evaluated potential pharmacodynamic herb-drug interaction of Hwangryunhaedok-tang (HRHDT) when co-administered with dapagliflozin in patients with type 2 diabetes mellitus (T2DM).
    Methods: In this retrospective study, patients with T2DM receiving both HRHDT and dapagliflozin were assessed for fasting blood sugar (FBS), 2-h postprandial glucose (PP2), and glycated hemoglobin (HbA1c) levels before and after co-administration. Liver enzymes and renal function parameters were evaluated for safety. Subgroup analyses were conducted based on insulin use and other oral hypoglycemic agents.
    Results: Twenty patients with T2DM co-administering HRHDT and dapagliflozin were included. No significant changes were observed in FBS, PP2, or HbA1c after HRHDT co-administration. Subgroup analyses also showed no significant glycemic differences. ALP, GGT, and BUN levels decreased, while other liver and renal parameters remained stable.
    Conclusions: Co-administration of HRHDT and dapagliflozin showed no pharmacodynamic interactions and no significant safety concerns.
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    Objective: This study evaluated potential pharmacodynamic herb-drug interaction of Hwangryunhaedok-tang (HRHDT) when co-administered with dapagliflozin in patients with type 2 diabetes mellitus (T2DM). Methods: In this retrospective study, patients wi...

    Objective: This study evaluated potential pharmacodynamic herb-drug interaction of Hwangryunhaedok-tang (HRHDT) when co-administered with dapagliflozin in patients with type 2 diabetes mellitus (T2DM).
    Methods: In this retrospective study, patients with T2DM receiving both HRHDT and dapagliflozin were assessed for fasting blood sugar (FBS), 2-h postprandial glucose (PP2), and glycated hemoglobin (HbA1c) levels before and after co-administration. Liver enzymes and renal function parameters were evaluated for safety. Subgroup analyses were conducted based on insulin use and other oral hypoglycemic agents.
    Results: Twenty patients with T2DM co-administering HRHDT and dapagliflozin were included. No significant changes were observed in FBS, PP2, or HbA1c after HRHDT co-administration. Subgroup analyses also showed no significant glycemic differences. ALP, GGT, and BUN levels decreased, while other liver and renal parameters remained stable.
    Conclusions: Co-administration of HRHDT and dapagliflozin showed no pharmacodynamic interactions and no significant safety concerns.

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