Effect of Graphene Oxide Incorporation into Electrospun Cellulose Acetate Scaffolds on Breast Cancer Cell Culture

다국어 초록 (Multilingual Abstract)

Graphene-based nanomaterials have been used as biomaterials to enhance cell adhesion, growth, anddifferentiation. However, the effect of graphene materials on cancer cell behavior has not been thoroughly investigated.
Herein, we have incorporated graphene oxide (GO) into cellulose acetate (CA) to develop nanofibrous scaffolds for in vitrocancer cell culture, which is a crucial step for drug screening and cancer research. The GO/CA scaffolds were seeded withbreast cancer cells and cell viability, proliferation, adhesion, infiltration, and morphology were assessed. Mechanicalcharacterization demonstrated that the mechanical properties of GO/CA scaffolds were significantly better than bare CAscaffold and improved with increasing GO content. More importantly, the in vitro cell studies showed that the cancer cells onGO/CA scaffolds had significantly higher viability and better cell adhesion and growth than bare CA. Our results confirm animportant role of GO in improving mechanical properties and cancer cell performance on GO/CA scaffolds. These resultssuggest the potential of the GO/CA scaffolds as a promising candidate for in vitro cancer models.

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