Preparation and Evaluation of Hydrogel using Thermosensitive chitosan-b-F127-b-chitosan tri-block copolymer for Cell delivery = Preparation and Evaluation of Hydrogel using Thermosensitive chitosan-b-F127-b-chitosan tri-block copolymer for Cell delivery

다국어 초록 (Multilingual Abstract)

Pluronic F127(poloxamer) is well known thermosensitive material, and it has a property of sol-gel phase transition in specific temperature. We synthesized thermo-sensitive chitosan-b-F127-b-chitosan tri-block copolymer by radical polymerization. The characterization of tri-block copolymer was analyzed by ¹H NMR, DSC, TGA, and rheological study. The value of a solid-like behavior (elastic modulus (G`)) and a liquidlike behavior(viscous modulus (G“)) was recorded according to changing temperature with parallel plate. Moreover, its sol-gel phase transition was confirmed by vial inversion method. These results suggest that tri-block copolymer can apply to biomaterial field for cell delivery. ^**This work was supported by the National Research Foundation of Korea(NRF) grant funded by the Ministry of Science, ICT & Future Planning. (NRF-2014R1A2A1A10053027)