급성 B 형간염 진단에서 IgM anti - HBc 측정의 의의 = A Clinical Significance of IgM anti - HBc in Diagnosis of Acute Viral Hepatitis B

다국어 초록 (Multilingual Abstract)

The following results and conclusions were reached by measuring IgM anti-HBc through radioimmunoassy in the 28 patients with acute viral hepatitis(including the 26 patients with acute viral hepatitis B), the 22 chronic HBsAg carriers, the 12 healthy HBsAg carriers, and the 21 healthy persons. 1) By means of the initial and follow-up test of 26 patients with acute viral hepatitis B, the test of total 51 samples ahowed that the 41 samples(80.4%) among them proved to positive (S/N ratio>2.1), and the S/N ratio of them as 5.7±3.3(M±SD) were statically-significantly higher(p.<0.001) than that of other groups of patients, making the differential diagnosis of the diseases possible. 2) In the course of the follow-up test of acute virul hepatitis B, the test was proved to be positive at the rate of 100% within a week, 86.7% around 30 days and 71.0% around 60 days after onset of clinical symptoms, being reduced to 51.0% till 180 days, whereas their S/N ratio proved to be 9.3±1.3 within a week, 6.8±2.3 around 30 days and 2.7±0.9 raound 60 days, showing rapidly reduced till 2 months. 3) Among the 26 patients diagnosed to be with acute viral hepatitis B, the initial test showed the 5 patients with negative HBsAg, all of whom proved to be with positive IgM anti-HBc and the S/N ratio of whom show the similar figure to the other patients with positive HBsAg. Therefore, acute viral hepatitis B with negative HBsAg could be diagnosed through measureing IgM anti-HBc. 4) Both of the 2 diagnosed not to be with acute viral hepatitis B among the 28 patients with acute viral hepatitis, ahowed poaitive IgM snti-HAV, diagnosed to be acute viral hepatitis A. 5) In the diagosis of acute viral hepatitis B, the sensitivity of IgM anti-HBc showed 80.4% till 180 days, but 100% within a week-test and 93,3% till a month, after the onset of symptoms, its specifity being 85.5%.