Effects of Trang Phuc Linh Plus-Food Supplement on Irritable Bowel Syndrome Induced by Mustard Oil

다국어 초록 (Multilingual Abstract)

Trang phuc linh plus (TPLP) is a food supplement product derived from dried extracts of herbal agents Atractylodes macrocephala, Poria cocos, Paeonia lactiflora, Phellodendron amurense, and added lactobacillus fermentum lysate (ImmuneGamma®) and 5-hydroxytryptophan. TPLP is a functional food used as adjunctive treatment for treating irritable bowel syndrome (IBS). However the biological effect and its mechanism of action in IBS have not been elucidated. In this study, we aimed to determine the pharmacological activities and mode of action of TPLP on IBS animal models. Mice were given a single administration of 5% mustard oil (MO) intracollonically. Acute colitis induction by MO resulted in later development of an IBS-like accelerated upper gastrointestinal transit in mice. Mice were treated with different does of TPLP and controls. Results showed that TPLP at the dose of 654 mg/kg/day given orally significantly decreased intestinal motility (IM) compared with the control animals. The effect was similar to Duspatalin (80 mg/kg/day) (Mebeverine Hydrochloride, an antispasmodic that helps to relieve the pain and discomfort associated with gastrointestinal spasms). Increased TPLP dose (1962 mg/kg/day) had a better effect on relief of IM than Duspatalin (80 mg/kg/day). TPLP also reduced peristalsis frequency and decreased fluid volume and electrolytes excretion in intestine tested in ex vivo models. Overall, TPLP may be an effective nutraceutical supplement for IBS.

참고문헌 (Reference)

1 Bensoussan A, "Treatment of irritable bowel syndrome with Chinese herbal medicine : A randomized controlled trial" 280 : 1585-1589, 1998

2 Holschneider DP, "The role of experimental models in developing new treatments for irritable bowel syndrome" 5 : 43-57, 2011

3 Jailwala J, "Pharmacologic treatment of the irritable bowel syndrome : A systematic review of randomized, controlled trials" 133 : 136-147, 2000

4 Olafsdottir LB, "Irritable bowel syndrome : Physicians’awareness and patients’ experience" 18 : 3715-3720, 2012

5 Talley NJ, "Irritable bowel syndrome : Definition, diagnosis and epidemiology" 13 : 371-384, 1999

6 Liu JP, "Herbal medicines for treatment of irritable bowel syndrome" CD004116-, 2006

7 Spiller R, "Guidelines on the irritable bowel syndrome : Mechanisms and practical management" 56 : 1770-1798, 2007

8 Talley NJ, "Evaluation of drug treatment in irritable bowel syndrome" 56 : 362-369, 2003

9 Waugh AWG, "Effect of Lactobacillus plantarum 299v treatment in an animal model of irritable bowel syndrome" 21 : 33-37, 2009

10 Vogel HG, "Drug Discovery and Evaluation: Pharmacological Assays" Springer-Verlag 1191-1322, 2008

11 Vogel HG, "Drug Discovery and Evaluation: Pharmacological Assays" Springer-Verlag 1246-1248, 2008

12 Kimball ES, "Acute colitis induction by oil of mustard results in later development of an IBS-like accelerated upper GI transit in mice" 288 : G1266-G1273, 2005