한국 소아 알레르기비염 환자의 삶의 질에 대한 설문 개발 및 유용성 평가를 위한 연구 = Development and Validation of the Questionnaire for Quality-of-Life Specific to Allergic Rhinitis in Korean Children (QQOL-ARK): A Multicenter Study한국 소아 알레르기비염 환자의 삶의 질에 대한 설문 개발 및 유용성 평가를 위한 연구

다국어 초록 (Multilingual Abstract)

Background: A questionnaire for assessing the quality of life (QOL) of children with allergic rhinitis has not been developed in Korea. Objective: Our study was designed to develop and validate a Questionnaire for QOL Specific to Allergic Rhinitis in Korean Children (QQOL-ARK). Method: The QQOL-ARK consisted of 4 domains including 18 items with a 5-point scale: symptoms (3 items), physical factors (8 items), psychosocial factors (6 items) and prognosis (1 item). A survey with the QQOL-ARK was performed on 168 children with allergic rhinitis twice, 4 weeks apart. We analyzed their responsiveness, reproducibility and validity. Result: The mean score of QOL according to the severity showed a statistically significant difference between the first and second visits (P＜0.01). The scores of QOL were decreased in the improved group (P＜0.01) and increased in the worsen group (P＜0.01). The differences in scores between the first and second visits showed a statistically significant difference in intergroup analysis (P＜0.01). The QQOL-ARK also showed a good reproducibility (R=0.97). There was no strong correlation between QOL and clinical severity. Conclusion: The QQOL-ARK showed a good reproducibility and validity. However, the assessment of reliability on 18 items of the questionnaire could not be performed. Although the items of this questionnaire are limited, they could provide the basis for the development of the QOL questionnaire for Korean children with allergic rhinitis in conjunction with clinical evaluation. (Korean J Asthma Allergy Clin Immunol 2009;29:242-248)

참고문헌 (Reference)

1 정민규, "한국 성인 알레르기 비염 환자의 삶의 질 평가를 위한 설문지 개발 및 유용성 평가를 위한 연구" 대한천식알레르기학회 28 (28): 113-120, 2008

2 박기환, "통년성 알레르기비염 환자의 삶의 질 평가를 위한 설문지- 제 1 보 -" 대한이비인후과학회 45 (45): 254-262, 2002

3 Juniper EF, "Validation of the standardized version of the rhinoconjunctivitis quality of life questionnaire" 104 : 364-369, 1999

4 de Graaf-in’t Veld T, "The relationships between nasal hyperreactivity, quality of life, and nasal symptoms in patients with perennial allergic rhinitis" 98 : 508-513, 1996

5 Arrighi HM, "The prevalence and impact of allergic rhinitis among teenagers" 97 : 430-, 1996

6 Woods L, "The importance of rhinitis on sleep, daytime somnolence, productivity and fatigue" 12 : 390-396, 2006

7 Weiss KB, "The health economics of asthma and rhinitis. I. Assessing the economic impact" 107 : 3-8, 2001

8 Juniper EF, "Rhinitis management: the patient’s perspective" 28 : S34-S38, 1998

9 Juniper E, "Rhinitis and quality of life" 41 : 111-115, 2001

10 Hong SJ, "Report of epidemiology study group for pediatric asthma and allergic disease" 17 (17): S55-S66, 2007

11 Lee HJ, "Relationship between symptom severity and subjective sleep disturbance in allergic rhinitis" 18 : 219-223, 2007

12 Meltzer EO, "Quality of life in adults and children with allergic rhinitis" 108 : S45-S53, 2001

13 Juniper EF, "Impact of upper respiratory allergic diseases on quality of life" 101 : S386-S391, 1998

14 Kremer B, "Generic or disease specific quality of life scales to characterize health status in allergic rhinitis?" 56 : 957-963, 2001

15 Schipper H, "Definitions and conceptual issues. in: Quality of life assessment in clinical trials" Raven Press 11-24, 1990

16 Guillemin F, "Cross-cultural adaptation of health-related quality of life measures: literature review and proposed guidelines" 46 : 1417-1432, 1993

17 Stuck BA, "Changes in daytime sleepiness, quality of life, and objective sleep patterns in seasonal allergic rhinitis: a controlled clinical trial" 113 : 663-668, 2004

18 Bousquet JB, "Assessment of quality of life in patients with perennial allergic rhinitis with the French version of the SF-36 Health Status Questionnaire" 94 : 182-188, 1994

19 David PS, "Allergic rhinitis: definition, epidemiology, pathophysiology, detection, and diagnosis" 108 : S2-S8, 2001

20 Jáuregui I, "Allergic rhinitis and school performance" 19 : 32-39, 2009

21 Bousquet J, "Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaborates with the World Health Organization, GA(2)LEN and AllerGen)" 63 (63): S8-S160, 2008