횐쥐에서 고혈당 및 고지질혈증이 운동 중 골격근 당원이용에 미치는 영향 = The Effects of Hyperglycemia and Hyperlipidemia on Muscle Glycogen Utilization during Exercise in Rate

다국어 초록 (Multilingual Abstract)

The effects of hyperglycemia and hyperlipidemia on utilization of muscle glycogen during 45 minute session of treadmill running (26 m/min, 8 % grade) were evaluated using Sprague Dawley rats, and the characteristics of the 4 different type of muscles, i.c., soleus, white and red gastrocnemius, and plantaris, on glycogen utilization were simultaneously investigated. Hyperglycemia was induced by 145-165 ㎎/dL of oral glucose administration, and hyperlipidemia was induced by combined treatment of intraperitoneal heparine injection of 444 uEq/L and 10 % intralipose oral adminstration. During the hyperglycemic trial, the glycogen utilization of plantaris muscle was decreased by 13 % in 45 minute session of treadmill running compared to the control trial (p<0.05), and the glycogen utilization of while gastrocnemius was also decreased. The sparing tendency of glycogen was observed in soleus and red gastrocnemius by 5-13 % during 30 and 45 minute session of treadmill running in hyperglycemic trial. There was no glycogen sparing effect of hyperlipidemia in soleus, red gastrocnemius and plantaris muscle subjected in this experiment during exercise. However, only a slight sparing tendency of white gastrocnemius muscle was observed. In summary, the glycogen sparing effect of hyperglycemia during exercise was observed in plantaris and white gastrocnemius muscles in rats. However, there was no glycogen sparing effect of hyperlipidemia in the 4 hindlimb muscles. It was observed that the glycogen sparing effect of hyperglycemia is more prominent in fast glycolytic muscle fibera.