<P><B>Abstract</B></P><P>MicroRNAs (miRNAs) are small, 18‐ to 22‐nucleotide non‐coding RNAs that regulate target gene expression. Although recent studies focused on various diseases that harbor the <I...
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https://www.riss.kr/link?id=A107653294
2012
-
SCI,SCIE,SCOPUS
학술저널
65-73(9쪽)
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
<P><B>Abstract</B></P><P>MicroRNAs (miRNAs) are small, 18‐ to 22‐nucleotide non‐coding RNAs that regulate target gene expression. Although recent studies focused on various diseases that harbor the <I...
<P><B>Abstract</B></P><P>MicroRNAs (miRNAs) are small, 18‐ to 22‐nucleotide non‐coding RNAs that regulate target gene expression. Although recent studies focused on various diseases that harbor the <I>miR‐146a</I>C>G (rs2910164), <I>149</I>C>T (rs2292832), <I>196a2</I>C>T (rs11614913), and <I>499</I>A>G (rs3746444) polymorphisms, the role of miRNA genetic variants in colorectal cancer is still unknown. The present study aimed to evaluate the role of four miRNA polymorphisms in patients with colorectal cancer. We enrolled 446 colorectal cancer patients and 502 control subjects from the Korean population. We found a significantly increased colorectal cancer risk with the <I>miR‐196a2</I>CC genotype compared with the TT/CT genotype (AOR = 1.50; 95% CI = 1.11–2.04; <I>P</I> = 0.01; FDR‐P = 0.04). In the stratified analyses, we observed both weak and strong association data. We found stronger associations of the <I>miR‐196a2</I> variants in the non‐diabetic and rectal cancer groups than other stratified groups. Our data suggest that the miRNA variants could affect the development of colorectal cancer in the Korean population. © 2011 Wiley Periodicals, Inc.</P>