제 3 회 한국키틴키토산연구회 심포지움 Proceeding : 아미노산으로 N - 콘쥬게이트된 키토산 올리고당 유도체의 합성 및 생리활성 = Synthesis and bioactivity of N - Conjugated Chitosan Oligosaccharide Derivatives With Amino Acids

다국어 초록 (Multilingual Abstract)

Antimicrobial activity of chitosan oligosaccharide (COS) derivatives N-conjugated with various amino acids(AA) have been investigated against E. coli. The syntheses of chitosan oligosaccharide derivatives (AA-COS) by DCC addition were carried out for reaction time 4hrs in a mixture solution with Immol of COS and 5mmol of AA and the degree of subsitution of AA-COS was 72.4% by ninhydrin method. All derivatives are greatly water-soluble. Asn-COS among all derivatives completely inhibited bacterial growth and had outstanding bactericidal activity. Antimicrobial action of Asn-COS might be dependent on the neighboring another free amino group at free amino group on back bone in the chemical structure of Asn-COS. These results suggest that Asn-COS would be useful as a new antibiotic agent.