지역사회 노인의 신체활동과 인지기능의 연관성 = Relationship between Physical Activity and Cognitive Function in the Elderly

다국어 초록 (Multilingual Abstract)

Background: Physical activity is considered an effective non-pharmaceutical preventive measure against cognitive impair- ment. This study was designed to investigate the correlation between physical activity and cognitive function.
Methods: Subjects were recruited from the Suwon Project, a cohort comprising a nonrandom convenience sample of ethnic Koreans aged 60 years or older. All participants completed study questionnaires which included questions about demographic characteristics, current and/or past medical history, and drug history. Cognitive functions were evaluated using the Korean version of Mini-Mental State Examination(K-MMSE), Korean version of Short Form Geriatric Depression Scale and Beck Anxiety Inventory. The total time spent to complete 10 physical activities was recorded on a daily basis.
Results: The total amount of time spent to execute 10 physical activities was 91.9±98.9 minutes per day. K-MMSE score was significantly associated with the duration of physical activity after adjustment for age, sex, educational level, depression, anxiety, and underlying diseases using multiple logistic regression analysis(β=0.002, p<0.05). Categorizing physical activities into three groups by intensity yielded an interesting result; moderate intensity group demonstrated a direct correlation with cognitive function(β=0.002, p<0.05).
Conclusion: Although much remains to be elucidated, our results suggest that physical activity may be associated with cognitive function, after controlling for covariates.

참고문헌 (Reference)

1 Abbott RD, "Walking and dementia in physically capable elderly men" 292 : 1447-1453, 2004

2 Attwell D, "The neural basis of functional brain imaging signals" 25 : 621-625, 2002

3 Plassman BL, "Systematic review: factors associated with risk for and possible prevention of cognitive decline in later life" 153 : 182-193, 2010

4 Etgen T, "Somatic factors in cognitive impairment" 77 : 72-82, 2009

5 Cho MJ, "Research on prevalence rate of dementia in the elderly" Seoul National University Hospital 2008

6 Lee Y ND, "Research on effectiveness of cognitive health promotion in the elderly and development of management guidelines" Ajou University, Management Center for Health Promotion 2009

7 Clarkson-Smith L, "Relationships between physical exercise and cognitive abilities in older adults" 4 : 183-189, 1989

8 Emery CF, "Psychological and cognitive outcomes of a randomized trial of exercise among patients with chronic obstructive pulmonary disease" 17 : 232-240, 1998

9 Middleton L, "Prevention of CIND by physical activity: different impact on VCI-ND compared with MCI" 269 : 80-84, 2008

10 Plassman BL, "Prevalence of cognitive impairment without dementia in the United States" 148 : 427-434, 2008

11 Graham JE, "Prevalence and severity of cognitive impairment with and without dementia in an elderly population" 349 : 1793-1796, 1997

12 Niti M, "Physical, social and productive leisure activities, cognitive decline and interaction with APOE-epsilon 4 genotype in Chinese older adults" 20 : 237-251, 2008

13 Weuve J, "Physical activity, including walking, and cognitive function in older women" 292 : 1454-1461, 2004

14 Sumic A, "Physical activity and the risk of dementia in oldest old" 19 : 242-259, 2007

15 Laurin D, "Physical activity and risk of cognitive impairment and dementia in elderly persons" 58 : 498-504, 2001

16 Sofi F, "Physical activity and risk of cognitive decline: a meta-analysis of prospective studies" 269 : 107-117, 2011

17 Etgen T, "Physical activity and incident cognitive impairment in elderly persons: the INVADE study" 170 : 186-193, 2010

18 Schuit AJ, "Physical activity and cognitive decline, the role of the apolipoprotein e4 allele" 33 : 772-777, 2001

19 Luck T, "Mild cognitive impairment in general practice: age-specific prevalence and correlate results from the German study on ageing, cognition and dementia in primary care patients (AgeCoDe)" 24 : 307-316, 2007

20 Lee Y, "Lifestyle recommendations for dementia prevention: PASCAL" 13 : 61-68, 2009

21 Verghese J, "Leisure activities and the risk of dementia in the elderly" 348 : 2508-2516, 2003

22 Craig CL, "International physical activity questionnaire: 12-country reliability and validity" 35 : 1381-1395, 2003

23 Cotman CW, "Exercise: a behavioral intervention to enhance brain health and plasticity" 25 : 295-301, 2002

24 Lytle ME, "Exercise level and cognitive decline: the MoVIES project" 18 : 57-64, 2004

25 Larson EB, "Exercise is associated with reduced risk for incident dementia among persons 65 years of age and older" 144 : 73-81, 2006

26 Singh-Manoux A, "Effects of physical activity on cognitive functioning in middle age: evidence from the Whitehall II prospective cohort study" 95 : 2252-2258, 2005

27 Bae JN, "Development of the Korean version of the Geriatric Depression Scale and its short form among elderly psychiatric patients" 57 : 297-305, 2004

28 Carmelli D, "Correlates of change in cognitive function in survivors from the Western Collaborative Group Study" 16 : 285-295, 1997

29 Ide K, "Cerebral metabolic response to submaximal exercise" 87 : 1604-1608, 1999

30 Miklossy J, "Cerebral hypoperfusion induces cortical watershed microinfarcts which may further aggravate cognitive decline in Alzheimer's disease" 25 : 605-610, 2003

31 Beck AT, "An inventory for measuring clinical anxiety: psychometric properties" 56 : 893-897, 1988

32 Hultsch DF, "Age differences in cognitive performance in later life: relationships to self-reported health and activity life style" 48 : P1-P11, 1993

33 Christensen H, "Activity levels and cognitive functioning in an elderly community sample" 25 : 72-80, 1996

34 Kang Y, "A validity study on the Korean mini-mental state examination (K-MMSE) in dementia patients" 15 : 300-308, 1997

35 Yook SP, "A clinical study on the Korean version of Beck Anxiety Inventory: comparative study of patient and non-patient" 16 : 185-197, 1997