큰느타리버섯(Pleurotus eryngii) 조다당체 분획의 항산화 및 항종양활성

국문 초록 (Abstract)

큰느타리 버섯으로부터 추출한 조다당체의 항산화 및 항암효과를 조사하였다. 항산화효과에 대한 실험에서 10, 100, 1,000 ㎍/mL 농도로 다당체의 처리시 linoleic acid에 대하여는 1,000 ㎍/mL 농도에서만 과산화물의 생성을 억제하였으나, 흰쥐의 microsome에 대하여는 각 농도에서 대조구에 비하여 5.3%, 9.4% 및 33%의 억제율을 나타내었다. 큰느타리버섯 다당체를 A549, MCF-7 및 AGS 암세포주에 같은 농도로 72시간 처리시 1,000 ㎍/mL 농도에서 대조구에 비하여 42.3, 33.4 및 26.7%의 증식억제 효과를 보였다. Sarcoma-180으로 복수암을 유발한 ICR mouse에 큰느타리버섯 다당체를 100 ㎎/㎏/day 및 300 ㎎/㎏/day의 농도로 7일간 처리하고 30일이 경과한 후 관찰한 결과 대조구에 비하여 각 농도에서 70% 및 90%의 수명연장 효과를 나타내었으며, 체중의 증가율도 대조구에 비하여 현저히 억제되었다.

다국어 초록 (Multilingual Abstract)

The aims of this study were to investigate the antioxidative and antitumor effects of crude polysaccharide fraction from Pleurtus eryngii (CPPE). CPPE inhibited autoxidation of linoleic acid at 1,000 ㎍/mL concentration, and the inhibitory rates of lipid peroxidation in rat liver microsome were 5.28, 9.40, and 32.5% at 10, 100, and 1,000 ㎍/mL concentrations, respectively. After treatment with CPPE for 72 hours, the inhibitory rates against MCF-7, A549 and AGS cell lines showed 42.3, 33.4 and 26.7% at concentration of 1,000 ㎍/mL, respectively. Results of CPPE treatment at 100 and 300 mg/kg/day for 7 days in sarcoma-180 bearing-mice showed survival rates of 70 and 90%, respectively. Body weights of mice treated with CPPE were significantly decreased when compared with the control.

목차 (Table of Contents)

• Abstract
  
• 서론
  
• 재료 및 방법
  
• 결과 및 고찰
  
• 요약
  
• 문헌

참고문헌 (Reference)

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