연폭로 근로자들에서 적혈구 Pyrimidine 5' -Nucleotidase 활성도 및 요중 N-Acetyl-β-D-Glucosaminidase 활성도의 상관관계 연구 = A Study of the Correlation Between the Activity of Erythrocyte Pyrimidine 5'-Nucleotidase and Urinary N-Acetyl-β-D-Glucosaminidase in Lead Exposed Workers

다국어 초록 (Multilingual Abstract)

In this study, we measured the activity of the erythrocyte pyrimidine 5'nucleotidaae(P5N) and urinary N-acetyl-(-D-glucoseminidase(NAG) from 154 workers exposed to lead and 43 Workers not exposed. We arialyzed the correlation of the P5N activity and NAG activity with other biological exposure indices of such as blood lead(PbB) and zinc protoporphyrin(ZPP). The measurement was performed by using high spectrophotometer.
The results are as follows'
1. The mean value of P%N activity for workers exposed to lead was 9.50±3.13 μmol uridine/hr/g Hb and 11.60±2.2 μmol uridine/hr/g Hb for workers not exposed.. The P5N actrvity showed a normal distribution, but the other indices of lead showed logarithmic normal distributions.
2. The P5N activity and ZPP were decreased as PbB was increased. But the NAG activity had no correlation with changes of PbB.
3. The correlation coefficients of the P5N activity with other biological exposure indices of lead such as PbB, ZPP, NAG activity were -0.72, -0.55, and 0.05, respectively.
We speculated that the P5N activity can be used as a reliable biological exposure index of lead but NAG activity can be used as a biological management index of lead.

목차 (Table of Contents)

• Abstract
• Ⅰ.서론
• Ⅱ.대상 및 방법
• Ⅲ.결과
• Ⅳ.고찰
• REFERENCES