컴퓨터를 이용한 3차원 입체조형치료에 대한 연구 = A Study on Computer-Controlled 3-D Conformal Radiotheraphy

다국어 초록 (Multilingual Abstract)

Image-based three dimensional radiation treatment planning(3D RTP) has a potential of generating superior treatment plans. Advances in computer technology and software developments quickly make 3D RTP a feasible choice for routine clinical use. However, it has become clear that evaluation of a 3D plan is more difficult than a 2D plan.
A number of tools has been developed to facilitate evaluation of 3D RTP both qualitatively and quantitatively. For example, beam's eye view(BEV) is one of the most powerful and time-saving method as a qualitative tool. Dose-volume histogram(DVH) has been proven to be one of the most valuable method for a quantitative tool. But it has a limitation to evaluate several different plans for biological effects of the tissue and critical organ. Therefore. there is a strong interest in developing quantitative models which would predict the likely biological response of irradiated organs and tissues. such as tumor control probability(TCP) and normal tissue complication probability(NTCP).
DVH and NTCP of hepatoma were evaluated for three dimensional conformal radiotherapy(3D CRT). Also, 3D RTP was analysed as a dose optimization based on beam arrangement and beam modulation.
The value of NTCP in patients with hepatitis was higher than that in patients without hepatitis. Also the value of n =0.32(volume factor) was highly correlated to prediction of radiation hepatitis. Therefore, we concluded that the possibility of radiation hepatitis was highly suggested if NTCP was over 40%.

목차 (Table of Contents)

• ABSTRACT = 61
• Ⅰ. 서론 = 62
• Ⅱ. 재료 및 방법 = 62
• 1. 임상 = 63
• 2. 치료계획 = 63
• 3. DVH와 NTCP의 비교, 분석 = 64
• Ⅲ. 결과 = 65
• Ⅳ. 결론 및 고찰 = 66
• 참고문헌 = 66