RISS 검색 - 국내학술지논문 상세보기

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다국어 초록 (Multilingual Abstract)

Objective; The aim of this study was to investigate difference of urinary leukotriene E4 (LTE4) in acute eosinophilic pneumonia (AEP), pneumonia and healthy control patients. Also, this study analyzed correlation between urinary LTE4 and important clinical parameters in AEP patients
Method; We prospectively enrolled AEP patients and pneumonia patients who were treated at Armed Forces Capital Hospital between June 2018 to December 2018. Also, we enrolled healthy control patients who visited for general health examination center. We gathered urinary samples from three study groups and analyzed differences of urinary LTE4 levels between groups. Also, we performed correlation analysis to reveal the association between urinary LTE4 and clinically important parameters including fever, peripheral WBC and eosinophil percentage, CRP, BAL eosinophil percentage, PaO2/FiO2, hospital days, fever day, O2 removal days
Results; Total of 50 patients in AEP group, 23 patients in pneumonia group and 26 patients in healthy control group were enrolled for analysis. Patients in AEP group showed more symptoms of dyspnea, higher WBC, peripheral eosinophilia and higher CRP compared to pneumonia group. Also, hospital days and O2 removal days were longer in AEP group compared to pneumonia group. Analysis of urinary LTE4 in three different group showed no statistically difference (healthy control vs pneumonia vs AEP; 2579.9±3087.3pg/mg vs 1771.1±1775.2pg/mg vs 2258.7±2218.5pg/mg, p-value=0.73). Correlation analysis showed positive correlation between urinary LTE4 with WBC and CRP. However, correlation analysis with other clinical parameters showed no statistically significance.
Conclusion; There was no difference in urinary LTE4 between AEP, pneumonia and healthy control. Also, there was positive correlation between urinary LTE4 with WBC and CRP in AEP patients, however, there was no significant correlation with PaO2/FiO2, hospital days, fever day or O2 removal days