왕호장근 뿌리 에탄올 추출물의 항산화 활성과 tyrosinase 활성 억제 효과 = Antioxidant Activity and Tyrosinase Inhibitory Effects of Fallopia sachalinensis Rhizome Ethanol Extract

다국어 초록 (Multilingual Abstract)

In this study, quantitative analysis of emodin and polydatin in Fallopia sachalinensis rhizome harvested from the Ulleung island was performed using HPLC. In addition, the antioxidant activity and tyrosinase inhibitory effects were examined. The concentrations of emodin and polydatin in the ethanolic total extract (TE) were 3.3346 and 4.3314 μg/mg, respectively. Emodin was mainly detected in the hexane fraction (HX, 8.7281 μg/mg) and polydatin in ethyl acetate fraction (EA, 40.5763 μg/mg). Antioxidant activity was evaluated using the DPPH radical scavenging assay. DPPH scavenging activity was detected in TE, HX and EA in dose-dependent manners. Of them, EA displayed the highest levels of DPPH scavenging activity (SC50: 29.17 μg/mL). Using the tyrosinase inhibition assay, we determined that EA had the highest capacity to suppress tyrosinase activity. Taken together, these results suggest that F. sachalinensis rhizome has the potential to be developed for functional food and in the cosmetic industry. However, studies on F. sachalinensis-specific compounds and their precise biological effects will need to be further examined.

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