C57BL/6 마우스에서 라벤더 오일이 모발성장 관련 효소활성과 싸이토카인 발현에 미치는 효과 = Effects of Lavender Oil on Hair Growth-Relevant Enzyme Activity and Cytokine Expression in C57BL/6 Mice

다국어 초록 (Multilingual Abstract)

The purpose of this study was to determine the effects of lavender oil (LO) on hair growth-relevant enzyme activity and cytokine expression in C57BL/6 mice. The experimental animals were divided into the following groups: i) normal (N: saline), ii) vehicle control (VC: jojoba oil), iii) positive control (PC: 3% minoxidil), iv) experimental 1 (E1: 3% LO), and v) experimental 2 (E2: 5% LO). Test compound solutions were topically applied to the backs of the mice (100 μL per application), once per day, 5 times a week, for 4 weeks. At week 4, the activities of γ-glutamyl transpeptidase (GT) in the E1 and E2 groups were 11% and 15% higher than the N group (p<0.05), respectively. The expression levels of keratinocyte growth factor (KGF) mRNA were significantly greater [10%; (p<0.05)] in the E1 and E2 groups, compared to the N group. The expression of insulin-like growth factor (IGF)-1 mRNA also significantly increased by 21% and 22% (p<0.05) in the E1 and E2 groups, compared to the N group, respectively. Hepatocyte growth factor (HGF) mRNA expression levels were significantly higher in the E1 and E2 groups than the N group [14% and 17%; (p<0.05)], respectively. The expression of vascular endothelial growth factor (VEGF) mRNA increased by 22% (p<0.05) in both the E1 and E2 groups, when compared to the N group. The correlation coefficients among hair growth-relevant factors were significantly high each other (p<0.001). The correlation coefficient between hair growth area and KGF mRNA expression was 0.940. These results confirm that LO has hair growth-promoting effects as identified by hair growth-relevant enzyme activity and cytokine expression in C57BL/6 mice.