표면항원과 항체가 동시 양성인 만성 B형 간염환자에서 표면항원 "a" 결정기 변이 분석

국문 초록 (Abstract)

B형 간염바이러스 표면항원에 대한 항체가 형성되면 HBsAg이 사라지고 HBV 감염으로부터 회복되는 것이 보편적이지만, HBsAg이 양성인 만성 간염 환자들 중 지속적으로 anti-HBs가 양성인 경우를 관찰할 수 있다. 이에 저자는 HBsAg과 anti-HBs가 동시에 양성인 만성 B형 간염환자에서 HBsAg S gene의?"a"?결정기 변이 존재 및 임상적 의의를 조사하였다. 53명의 환자 중 47명은 표면항원과 항체가 동시에 양성이었으며, 6명은 표면항원만 양성인 환자였다. 53명의 환자 중 17명(32.1%)이?"a"?결정기 변이가 관찰되었다. 시험군의 4명과 대조군의 1명은?"a"?결정기에 최소한 2개 이상의 변이가 관찰되었다. 가장 빈번한 변이 부위는 aa126, aa131 그리고 aa133였다. 이상의 결과로써 HBsAg과 anti-HBs가 동시에 양성인 B형 간염 환자에서 숙주의 면역체계를 벗어날 수 있는 HBsAg?"a"?결정기 부위에 다수의 변이가 있음을 확인하였다.

다국어 초록 (Multilingual Abstract)

Serologic markers are used to screen and diagnosis hepatitis B virus(HBV) infection. After an infection with HBV, hepatitis B surface antigen(HBsAg) is the first virologic marker detectable in the serum. If anti-HBs against?"a"?determinant of HBsAg appears, HBsAg will be disappeared and the patients will recover from the HBV infection in most cases. However, the coexistence cases of HBsAg and anti-HBs were frequently observed. The author investigated the clinical significance and presence of mutations of "a"?determinant in the S gene of chronic hepatitis B patients with coexisting HBsAg and anti-HBs. 47 out of the 53 patients were both positive for HBsAg and anti-HBs, 6 were positive for HBsAg only. 17(32.1%) mutations were found within the?"a"?determinant of HBV in the 53 patients. 4 patients from the test group, but only 1 from the control group, presented at least two residue changes in the?"a"?determinant. The most frequent changes in the test group were located at positions aa126, aa131, and aa133. These results demonstrated the presence of mutations at HBsAg?"a"?determinant in chronic hepatitis B patients with concurrent HBsAg and anti-HBs

목차 (Table of Contents)

• 요약
• Abstract
• Ⅰ. 서론
• Ⅱ. 대상 및 방법
• Ⅲ. 결과
• Ⅳ. 고찰
• 참고문헌
• 저자소개

참고문헌 (Reference)

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