Preparation and characterization of UV-curable carrageenan derivatives to coat collagen sheet for BMP-2 releasing = Preparation and characterization of UV-curable carrageenan derivatives to coat collagen sheet for BMP-2 releasing

다국어 초록 (Multilingual Abstract)

The Purpose of this study was photo-immobilization of BMP-2 using prepared azido-carrageenan derivative (Az-Carr) on collagen sheets and confirmed the effect of bone regeneration by release of the protein. Carrageenan as natural polymer had properties that it was biocompatible, low toxic, anti-viral activity and anti-coagulant for application to medical field. And, carrageenan was used in food and pharmaceutical applications for its gelling and thickening. Prepared Az-Carr identified by ¹H-NMR and uv/vis spectrophotometer. Az-Carr was evaluated drug immobilization and releasing control with BSA protein using protein releasing test. To confirm enhanced bone regeneration, Ca²⁺, ALP assay and Alizarin Red S staining were performed. ^**Acknowledgements : This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and future Planning (No. NRF-2014R1A2A1A11052623)