Drug-eluting gel using furfuryl chitosan derivatives to prevent post-operation adhesion = Drug-eluting gel using furfuryl chitosan derivatives to prevent post-operation adhesion

다국어 초록 (Multilingual Abstract)

Chitosan is a natural polymer that has beneficial properties such as less toxic, biodegradable, and biocompatible than synthetic polymers. Visible light-curable furfuryl chitosan derivatives(F-LMC) had been prepared by introducing furfuryl groups to amino groups of low molecular weight chitosan to prevent post-operation adhesion. The prepared F-LMC was characterized by ¹H NMR and GPC analysis. Photo curing of F-LMC is occurred by a photo-oxidation-induced cross-linking mechanism. The cross-linking was determined by concentration of F-LMC and time of exposure to visible light. The cytotoxicity test using fibroblast 3T3 showed no toxicity of F-LMC. Cross-linked F-LMC surface inhibited cell adhesion. Prepared F-LMC is a novel candidate to prevent post-operation adhesion.