본 연구는 streptozotocin으로 당뇨병을 유도하는 조건들을 농도에 따른 변화를 관찰하고, 적절한 조건에서 당뇨쥐에서의 저강도의 treadmill 운동이 체중과 혈중의 당, 인슐린 및 지질의 변화에 ...
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https://www.riss.kr/link?id=A103756970
2004
Korean
KCI등재
학술저널
245-251(7쪽)
0
0
상세조회0
다운로드국문 초록 (Abstract)
본 연구는 streptozotocin으로 당뇨병을 유도하는 조건들을 농도에 따른 변화를 관찰하고, 적절한 조건에서 당뇨쥐에서의 저강도의 treadmill 운동이 체중과 혈중의 당, 인슐린 및 지질의 변화에 ...
본 연구는 streptozotocin으로 당뇨병을 유도하는 조건들을 농도에 따른 변화를 관찰하고, 적절한 조건에서 당뇨쥐에서의 저강도의 treadmill 운동이 체중과 혈중의 당, 인슐린 및 지질의 변화에 미치는 영향을 알아보고자 실시하였으며, 연구결과를 요약하면 다음과 같다. 실험 I에서 STZ 주사량이 40 mg/mg으로 높아질수록 정상군에 비해 혈당이 유의하게 증가하고, 반대로 체중과 인슐린 농도는 상대적으로 감소하였다. 실험II에서 STZ 주사를 한 모든 군에서 혈당이 유의하게 증가하지만 BE군은 C군에 비해 그 증가율이 유의하게 억제되었으며, 운동이 인슐린 농도와 혈중지질 농도를 정상적으로 유도하는 것으로 나타났다. 특히, 당뇨 유발 전부터 운동을 실시한 경우 그 효과가 더욱 유의하게 나타났으며, 앞으로 당뇨 유발의 정도와 운동 빈도 및 강도와 관련된 더욱 많은 연구가 이루어져야 할 것으로 사료된다.
다국어 초록 (Multilingual Abstract)
Exercise is beneficial to the diabetic patients and streptozotocin-induced diabetic rat has been used for the study of exercise effect. The purpose of this study was to establish the optimal condition of induction of hyperglycemic diabetic rat using s...
Exercise is beneficial to the diabetic patients and streptozotocin-induced diabetic rat has been used for the study of exercise effect. The purpose of this study was to establish the optimal condition of induction of hyperglycemic diabetic rat using streptozotocin and to examine the preventive effect of treadmill exercise on the diabetic rat before and after streptozotocin injection. Intraperitoneal injection of increasing amount of streptozotocin up to 40 mg/kg dose-responsively induce hyperglycemic diabetic rat and inversely reduced the blood insulin level. Body weight was also gradually reduced with the increasing amount of streptozotocin. Control and diabetic rats exercised for 4 weeks before streptozotocin injection. The exercise was performed in the treadmill for 25 minutes a day and 5 times a week with low intensity (0 degree tilt, 15 m/min velocity). Following streptozotocin injection, the blood glucose level was measured every week and the rat was sacrificed after 4 weeks to measure the concentration of insulin and blood lipids. The blood levels of glucose and insulin was significantly reduced with exercise before streptozotocin injection, while those were not changed after streptozotocin injection. The levels of blood lipids such as total cholesterol, HDL-cholesterol, LDL-cholesterol and triglyceride were close to normal control rats. From this study, researchers found the optimal condition of preparation of streptozotocin-induced hyperglycemic diabetic rat, and the mild treadmill exercise has beneficial effect on preventing hyperglycemia and hyperlipidemia. Thus, even low intensive running prevent not only diabetes but also diabetic vascular complications.
참고문헌 (Reference)
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1 "Treadmill exercise suppresses diabetes-induced increment of neuropeptide Y expression in the hypothalamus of rats" 346 (346): 157-160, 2003
2 "The role of fat in autoimmune diabetes" 89 : 17-24, 1997
3 "The medical clinics of North America" 1985
4 "The mechanism of alloxan and streptozotocin action in cells of the rat pancreas" 50 : 536-546, 2001
5 "The effect of metformin on insulin receptors and lipid perosidation in alloxan and streptozotocin induced diabetes" 1995
6 "Streptozotocin alters pancreatic beta-cell responsiveness to glucose within six hours of injection into rats" 45 : 60-62, 1996
7 "Specific enhancement in GLUT2 expressing cells" 1326-43 1333, 1994
8 "Short-term insulin treatment prevents the diabetogenic action of streptozotocin in rats" 138 : 62-68, 1997
9 "Role of exercise training in the prevention and treatment of insulin resistance and non-insulin-dependent diabetes mellitus" 24 : 321-336, 1997
10 "Relative importance of transport and alkylation for pancreatic beta-cell toxicity of streptozotocin" 25 : 595-603, 2000
11 "Protective effect of pioglitazone against multiple low-dose streptozotocin- induced diabetes in rats" 25 (25): 205-208, 2003
12 "Physical exercise prevents the development of type 2 diabetes mellitus in Psammomys obesus" 282 : 370-375, 2002
13 "Nitric oxide generation during cellular metabolization of the diabetogenic N-methyl- N-nitroso-urea streptozotocin contributes to islet cell DNA damage" 376 : 179-185, 1995
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21 "Exercise down-regulates hepatic fatty acid synthase in streptozotocin treated rats" 131 (131): 2252-2259, 2001
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Vibrio parahaemolyticus collagenase 불활성화 돌연변이체의 제조 및 특성
김 추출물이 갱년기 장애 유도 흰쥐의 혈 중 지질 변화에 미치는 영향
동해안 고유종 긴잎돌김(Porphyra pseudolinearis)의 생태학적 연구
Biosurfactant 생산균주 Bacillus sp. TBM 911-5의 분리 및 특성
학술지 이력
연월일 | 이력구분 | 이력상세 | 등재구분 |
---|---|---|---|
2027 | 평가예정 | 재인증평가 신청대상 (재인증) | |
2021-01-01 | 평가 | 등재학술지 유지 (재인증) | |
2018-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2015-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2011-08-03 | 학술지명변경 | 외국어명 : Korean Journal of Life Science -> Journal of Life Science | |
2011-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2009-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2007-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2004-01-01 | 평가 | 등재학술지 선정 (등재후보2차) | |
2003-01-01 | 평가 | 등재후보 1차 PASS (등재후보1차) | |
2001-07-01 | 평가 | 등재후보학술지 선정 (신규평가) |
학술지 인용정보
기준연도 | WOS-KCI 통합IF(2년) | KCIF(2년) | KCIF(3년) |
---|---|---|---|
2016 | 0.37 | 0.37 | 0.42 |
KCIF(4년) | KCIF(5년) | 중심성지수(3년) | 즉시성지수 |
0.43 | 0.43 | 0.774 | 0.09 |