환경호르몬과 신경계질환 = Environmental Endocrine Disruptors and Neurological Disorders

다국어 초록 (Multilingual Abstract)

We live in a world where daily exposure to environmental chemicals is inevitable. Many studies point to environmental chemicals a major cause of neurological diseases. Properly intervening in and managing the exposure requires up-to-date information about neurotoxic chemicals that may lead to neurological disorders. The recent literature on the neurotoxic effects of environmental chemicals was reviewed, including both animal and human studies. Parkinson’s disease, Alzheimer’s disease and autism are closely associated with environmental chemicals such as polychlorinated biphenys (PCBs), dioxins, polybrominated biphenyl ethers (PBDE), and perfluoroalkyls. There is strong evidence linking environmental chemical exposure to neurodevelopmental and neurodegenerative diseases. In particular, it is important to pay close attention to a high risk-age group where the window of exposure is critical to causing neurological disease.

참고문헌 (Reference)

1 Stockholm Convention, "What Are POPs? [online]"

2 van den Berg M, "WHO/UNEP global surveys of PCDDs, PCDFs, PCBs and DDTs in human milk and benefit-risk evaluation of breastfeeding" 91 : 83-96, 2017

3 Kodavanti PRS, "Veterinary toxicology" Academic Press 675-686, 2018

4 Meng J, "Traditional and new POPs in environments along the Bohai and Yellow Seas: an overview of China and South Korea" 169 : 503-515, 2017

5 Tilson HA, "The neurotoxicity of polychlorinated biphenyls" 19 : 517-525, 1998

6 Caspersen IH, "The influence of maternal dietary exposure to dioxins and PCBs during pregnancy on ADHD symptoms and cognitive functions in Norwegian preschool children" 94 : 649-660, 2016

7 Mariussen E, "The effect of polychlorinated biphenyls on the high affinity uptake of the neurotransmitters, dopamine, serotonin, glutamate and GABA, into rat brain synaptosomes" 159 : 11-21, 2001

8 Kodavanti PR, "Structure-activity relationships of potentially neurotoxic PCB congeners in the rat" 18 : 425-442, 1997

9 Pesatori AC, "Short- and long-term morbidity and mortality in the population exposed to dioxin after the Seveso accident" 41 : 127-138, 2003

10 Stein CR, "Serum perfluorinated compound concentration and attention deficit/hyperactivity disorder in children 5-18 years of age" 119 : 1466-1471, 2011

11 Genskow KR, "Selective damage to dopaminergic transporters following exposure to the brominated flame retardant, HBCDD" 52 : 162-169, 2015

12 Angelova PR, "Role of mitochondrial ROS in the brain: from physiology to neurodegeneration" 592 : 692-702, 2018

13 Polanska K, "Review of current evidence on the impact of pesticides, polychlorinated biphenyls and selected metals on attention deficit / hyperactivity disorder in children" 26 : 16-38, 2013

14 Shah-Kulkarni S, "Prenatal exposure to perfluorinated compounds affects thyroid hormone levels in newborn girls" 94 : 607-613, 2016

15 Roze E, "Prenatal exposure to organohalogens, including brominated flame retardants, influences motor, cognitive, and behavioral performance at school age" 117 : 1953-1958, 2009

16 Yang JH, "Possible molecular targets of halogenated aromatic hydrocarbons in neuronal cells" 280 : 1372-1377, 2001

17 Aoki Y, "Polychlorinated biphenyls, polychlorinated dibenzo-p-dioxins, and polychlorinated dibenzofurans as endocrine disrupters; what have we learned from Yusho disease" 86 : 2-11, 2001

18 Safe S, "Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs)" 21 : 51-88, 1990

19 Fitzgerald EF, "Polybrominated biphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs) and neuropsychological status among older adults in New York" 33 : 8-15, 2012

20 Lee YJ, "Perfluorooctane sulfonate-induced apoptosis of cerebellar granule cells is mediated by ERK 1/2 pathway" 90 : 1597-1602, 2013

21 Caudle WM, "Parkinson's disease and the environment: beyond pesticides" 33 : 585-, 2012

22 Oliaei F, "PFOS and PFC releases and associated pollution from a PFC production plant in Minnesota (USA)" 20 : 1977-1992, 2013

23 Kodavanti PRS, "Neurotoxicity of persistent organic pollutants: possible mode(s) of action and further considerations" 3 : 273-305, 2006

24 Fonnum F, "Mechanisms involved in the neurotoxic effects of environmental toxicants such as polychlorinated biphenyls and brominated flame retardants" 111 : 1327-1347, 2009

25 Cheslack-Postava K, "Maternal serum persistent organic pollutants in the Finnish Prenatal Study of Autism: a pilot study" 38 : 1-5, 2013

26 Inglefield JR, "Inositol 2,4,5-triphosphate receptor- sensitive $Ca^{2+}$ release, store-operated $Ca^{2+}$ entry, and cAMP responsive element binding protein phosphorylation in developing cortical cells following exposure to polychlorinated biphenyls" 297 : 762-773, 2001

27 Lombardo JP, "Inhalation of Polychlorinated Biphenyls (PCB) Produces Hyperactivity in Rats" 78 : 1142-1153, 2015

28 Jurewicz J, "Exposure to widespread environmental toxicants and children's cognitive development and behavioral problems" 26 : 185-204, 2013

29 Heyer DB, "Environmental toxicology: sensitive periods of development and neurodevelopmental disorders" 58 : 23-41, 2017

30 Provost TL, "Dose- and age-dependent alterations in choline acetyltransferase (ChAT) activity, learning and memory, and thyroid hormones in 15- and 30-day old rats exposed to 1.25 or 12.5 ppm polychlorinated biphenyl (PCB) beginning at conception" 23 : 915-928, 1999

31 Ash PEA, "Dioxins and related environmental contaminants increase TDP-43 levels" 12 : 35-49, 2017

32 Berghuis SA, "Developmental neurotoxicity of persistent organic pollutants: an update on childhood outcome" 89 : 687-709, 2015

33 Lam J, "Developmental PBDE exposure and IQ/ADHD in childhood: a systematic review and meta-analysis" 125 : 086001-, 2017

34 Wong S, "Autism, mitochondria and polybrominated diphenyl ether exposure" 15 : 614-623, 2016

35 Su FC, "Association of environmental toxins with amyotrophic lateral sclerosis" 73 : 803-811, 2016

36 Hatcher-Martin JM, "Association between polychlorinated biphenyls and Parkinson's disease neuropathology" 33 : 1298-1304, 2012

37 Kim S, "Association between maternal exposure to major phthalates, heavy metals, and persistent organic pollutants, and the neurodevelopmental performances of their children at 1 to 2years of age- CHECK cohort study" 624 : 377-384, 2017

38 Yang JH, "Alterations in brain protein kinase C isoforms following developmental exposure to polychlorinated biphenyl mixture" 111 : 123-135, 2003

39 WHO, "Almost a quarter of all disease caused by environmental exposure. [online]"

40 Denison MS, "Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals" 43 : 309-334, 2003

41 Lee YJ, "AMP-activated protein kinase is involved in perfluorohexanesulfonate-induced apoptosis of neuronal cells" 149 : 1-7, 2016

42 Chen YC, "A 6-year follow-up of behavior and activity disorders in the Taiwan Yu-Cheng children" 84 : 415-421, 1994