Sophisticated Plasmonic Nanomaterial as the Photo-Nanozyme for Dynamic Cancer Therapy under NIR Light = Sophisticated Plasmonic Nanomaterial as the Photo-Nanozyme for Dynamic Cancer Therapy under NIR Light

다국어 초록 (Multilingual Abstract)

The utilization of nanomaterials as the nanozyme for dynamic cancer therapy received significant attention from the scientific community. Especially, the noble plasmonic nanomaterials have huge potential due to the intrinsic properties of noble metals, localized surface plasmon resonance (LSPR), and photothermal effect to not only induce the generation of reactive oxygen species (ROS) but also generate enough heat for cancer therapy. Herein, we synthesized uniform gold nanobipyramids, with selective deposition of palladium nanoparticles at the end. Upon laser irradiation, we observed significantly enhanced peroxidase-like activities of our materials due to facile collection of induced hot carriers at the incorporated Pd centers. Also, LSPR induced thermal effect was incorporated to our system to induce synergistic photothermal and dynamic therapy. Our work highlights the ability of this novel and highly efficient hybrid nanocomposite as a NIR-responsive tumor catalytic therapy.