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      백편두(白扁豆), 가자(訶子) 및 보장건비탕(補腸健脾湯)의 항사하작용(抗瀉下作用)에 관(關)한 연구(硏究) = Experimental Studies on the Anti-cathartic Effects of Dolichoris Semen, Terminaliae Fructus and Bojanggunbi-tang

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      https://www.riss.kr/link?id=A100743252

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      다국어 초록 (Multilingual Abstract)

      Objectives: The aim of this experimental study is to investigate effects of Dolichoris Semen, Terminaliae Fructus and Bojanggunbi-tangon the anti-cathartic action of mice and guinea pigs to develop effective herbal medicine and prescription to cure diarrhea early and to prevent side effect of chronic diarrhea. Methods: To compare effects of Dolichoris Semen, Terminaliae Fructus and Bojanggunbi-tangon the anti-cathartic action of mice and guinea pigs, we evaluated the actions on isolated gastrointestinal smooth muscles. on the transportability of small and large intestines, onthe neostigmine-induced transportability of small intestine and on diarrhea induced by castor oil, pilocarpine, barium chloride. Results: (1) Dolichoris Semen, Terminaliae Fructus and Bojanggunbi-tang showed the strong alleviation on the contraction of mice's isolated gastrointestinal smooth muscles induced by acetylcholine chloride and barium chloride. while Terminaliae Fructus, strong, Bojanggunbi-tang, intermediate and Dolichoris Semenshowed the minor alleviation on the contraction of guinea pigs' isolated gastrointestinal smooth muscles induced by acetylcholine chloride and histamine. All effects depended on the density in each medicine. (2) The tranbportability of small intestine was contrained in the groups controlled by 600 mg/kg of Dolichoris Semen, Terminaliae Fructus and Bojanggunbi-tang, and 200 mg/kg of D olichoris Semen and Terminaliae Fructus. However, the enhancement of neostigmine-induced transportability of small intestine was constrained only in the groups controlled by 600 mg/kg of Dolichoris Semen, Terminaliae Fructus and Boianggunbi-tang. (3) The transportability of large intestine was constrained by Dolichoris Semen and Bojanggunbi-tang. They showed substantial results. which depended on the amount of each medicine. (4) Terminaliae Fructus showed substantial anti-cathartic effects on diarrhea induced by caster oil in both groups controlled by 200 and 600 mg/kg of it. However, Bojanggunbi-tangshowed the effects only in the group controlled by 600 mg/kg. in diarrhea induced by pilocarpine, the groups controlled by 600 mg/kg or Terminaliae Fructus and 200 and 600 mg/kg of Boianggnbi-tangshowed substantial results. In diarrhea induced by barium chloride. the groups controlled by 200 and 600 mg/kg of Terminaliae Fructus and 600 mg/kg of Boianggunbi-tangshowed substantial results in anti-cathartic effects. Conclusions: These results show that Terminaliae Fructus is more effective on the contraction of mice and guinea pigs' isolated gastrointestinal smooth muscles, Dolichoris Semen is more effective on the transportability of small intestine, Dolichoris Semen and Bojanggunbi-tang are more effective on the transportability of large intestine. Terminaliae Fructus and Bojanggunbi-tang show substantial results in anti-cathartic actions.
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      Objectives: The aim of this experimental study is to investigate effects of Dolichoris Semen, Terminaliae Fructus and Bojanggunbi-tangon the anti-cathartic action of mice and guinea pigs to develop effective herbal medicine and prescription to cure di...

      Objectives: The aim of this experimental study is to investigate effects of Dolichoris Semen, Terminaliae Fructus and Bojanggunbi-tangon the anti-cathartic action of mice and guinea pigs to develop effective herbal medicine and prescription to cure diarrhea early and to prevent side effect of chronic diarrhea. Methods: To compare effects of Dolichoris Semen, Terminaliae Fructus and Bojanggunbi-tangon the anti-cathartic action of mice and guinea pigs, we evaluated the actions on isolated gastrointestinal smooth muscles. on the transportability of small and large intestines, onthe neostigmine-induced transportability of small intestine and on diarrhea induced by castor oil, pilocarpine, barium chloride. Results: (1) Dolichoris Semen, Terminaliae Fructus and Bojanggunbi-tang showed the strong alleviation on the contraction of mice's isolated gastrointestinal smooth muscles induced by acetylcholine chloride and barium chloride. while Terminaliae Fructus, strong, Bojanggunbi-tang, intermediate and Dolichoris Semenshowed the minor alleviation on the contraction of guinea pigs' isolated gastrointestinal smooth muscles induced by acetylcholine chloride and histamine. All effects depended on the density in each medicine. (2) The tranbportability of small intestine was contrained in the groups controlled by 600 mg/kg of Dolichoris Semen, Terminaliae Fructus and Bojanggunbi-tang, and 200 mg/kg of D olichoris Semen and Terminaliae Fructus. However, the enhancement of neostigmine-induced transportability of small intestine was constrained only in the groups controlled by 600 mg/kg of Dolichoris Semen, Terminaliae Fructus and Boianggunbi-tang. (3) The transportability of large intestine was constrained by Dolichoris Semen and Bojanggunbi-tang. They showed substantial results. which depended on the amount of each medicine. (4) Terminaliae Fructus showed substantial anti-cathartic effects on diarrhea induced by caster oil in both groups controlled by 200 and 600 mg/kg of it. However, Bojanggunbi-tangshowed the effects only in the group controlled by 600 mg/kg. in diarrhea induced by pilocarpine, the groups controlled by 600 mg/kg or Terminaliae Fructus and 200 and 600 mg/kg of Boianggnbi-tangshowed substantial results. In diarrhea induced by barium chloride. the groups controlled by 200 and 600 mg/kg of Terminaliae Fructus and 600 mg/kg of Boianggunbi-tangshowed substantial results in anti-cathartic effects. Conclusions: These results show that Terminaliae Fructus is more effective on the contraction of mice and guinea pigs' isolated gastrointestinal smooth muscles, Dolichoris Semen is more effective on the transportability of small intestine, Dolichoris Semen and Bojanggunbi-tang are more effective on the transportability of large intestine. Terminaliae Fructus and Bojanggunbi-tang show substantial results in anti-cathartic actions.

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      참고문헌 (Reference)

      1 "소화기계 질환" 일조각 52-62, 2000

      2 "韓醫學大辭典" 圖書出版 鼎談 1678-, 1998

      3 "韓藥臨床應用" 成輔社 147-, 1998

      4 "韓方基本處方集" 慶熙센터 1983

      5 "諸病源候論(上" 北京 1983-, 人民衛生出版社

      6 "補腸健脾湯의 效能에 關한 實驗的硏究" 15 (15): 83-99, 1994

      7 "補腸健脾湯과 訶子가 胃腸管에 미치는 影響에 관한 實驗的硏究" 東國大學校大學院 1989

      8 "聖濟總錄(文淵閣四庫全書卷739" 서울 1988-, 驪江出版社

      9 "編註醫學入門" 大成文化社 1986

      10 "白朮散과 白扁豆가 白鼠 小腸과 大腸 杯狀細胞內 粘液質에 미치는 影響" 東國大學校大學院 1991

      1 "소화기계 질환" 일조각 52-62, 2000

      2 "韓醫學大辭典" 圖書出版 鼎談 1678-, 1998

      3 "韓藥臨床應用" 成輔社 147-, 1998

      4 "韓方基本處方集" 慶熙센터 1983

      5 "諸病源候論(上" 北京 1983-, 人民衛生出版社

      6 "補腸健脾湯의 效能에 關한 實驗的硏究" 15 (15): 83-99, 1994

      7 "補腸健脾湯과 訶子가 胃腸管에 미치는 影響에 관한 實驗的硏究" 東國大學校大學院 1989

      8 "聖濟總錄(文淵閣四庫全書卷739" 서울 1988-, 驪江出版社

      9 "編註醫學入門" 大成文化社 1986

      10 "白朮散과 白扁豆가 白鼠 小腸과 大腸 杯狀細胞內 粘液質에 미치는 影響" 東國大學校大學院 1991

      11 "日 比野隆二" 1969

      12 "完譯中藥大辭典" 圖書出版 鼎談 5839-5842, 1998

      13 "增補萬病回春" 杏林書院 1972

      14 "丹溪心法附餘(上" 서울 1982-, 大成文化社

      15 "中醫學問答(下冊" 北京 1985-, 人民衛生出版社

      16 "Studies of Aloe Mechanism of Cathritic Effect" taki : 1988

      17 "Studies of Aloe" taki : 1981

      18 "Purgative activity of Daio-kanzo-to in rats-potentiating effect of glycyrrhiza on the purgative action of rhubarb" and kuwa : 1993

      19 "Pharmacological studies on antidiarrheal effects of berberine and Geranii Herba" 1993

      20 "Pharmacological studies on antidiarrheal effects of a preparation containing Berberine and Geranii Herba" 1993

      21 "Inhibitory actions of laxatives on motility and water and electrolyte transport in the gastrointestinal-tract" 1975

      22 "Effects of Keishi ka shakuyaku to Gui Zhi Jia Yao Tang on diarrrhea and small intestinal movement" 22 : 87-, 1999

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      학술지 이력

      학술지 이력
      연월일 이력구분 이력상세 등재구분
      2022 평가예정 재인증평가 신청대상 (재인증)
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      2015-12-01 평가 등재후보로 하락 (기타) KCI등재후보
      2011-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2009-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2006-02-09 학술지명변경 외국어명 : THE KOREAN SOCIETY FOR ORIENTAL INTERNAL MEDICINE -> The Journal of Korean Oriental Internal Medicine KCI등재
      2006-01-01 평가 등재학술지 선정 (등재후보2차) KCI등재
      2005-01-01 평가 등재후보 1차 PASS (등재후보1차) KCI등재후보
      2003-01-01 평가 등재후보학술지 선정 (신규평가) KCI등재후보
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      학술지 인용정보

      학술지 인용정보
      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 0.67 0.67 0.61
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      0.56 0.5 0.653 0.03
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