Changes in Muscular Lipids in Unilateral Isolated Hypertrophy of Gastrocnemius Muscle Can Be Revealed by 1H MR Spectroscopy

다국어 초록 (Multilingual Abstract)

Objective: To test whether proton magnetic resonance spectroscopy (1H-MRS) reveals changes in the lipid content of the gastrocnemius muscle (GM) and soleus muscle (SOL) of a patient with unilateral isolated hypertrophy of the right GM.
Materials and Methods: 1H-MRS was performed on a 1.5 Tesla (T) wholebody unit. Muscular lipids inside SOL and GM were assessed in both calves of the patient by a STEAM (stimulated echo acquisition mode) localization sequence. Results were compared to a control group of four healthy volunteers.
Results: Total amount of muscular lipids in the hypertrophic GM of the patient was clearly increased compared to the controls (38.7 versus 21.8±3.5 a.u.) while intramyocellular lipids of the adjacent SOL were lower compared to the contralateral healthy leg.
Conclusion: Muscular lipids are substrates for metabolism and can be assessed non-invasively by 1H-MRS. 1H-MRS is considered to be a helpful tool in clinical assessment of muscle metabolism in cases with muscular hypo- or hypertrophy.

다국어 초록 (Multilingual Abstract)

Objective: To test whether proton magnetic resonance spectroscopy (1H-MRS) reveals changes in the lipid content of the gastrocnemius muscle (GM) and soleus muscle (SOL) of a patient with unilateral isolated hypertrophy of the right GM.
Materials and Methods: 1H-MRS was performed on a 1.5 Tesla (T) wholebody unit. Muscular lipids inside SOL and GM were assessed in both calves of the patient by a STEAM (stimulated echo acquisition mode) localization sequence. Results were compared to a control group of four healthy volunteers.
Results: Total amount of muscular lipids in the hypertrophic GM of the patient was clearly increased compared to the controls (38.7 versus 21.8±3.5 a.u.) while intramyocellular lipids of the adjacent SOL were lower compared to the contralateral healthy leg.
Conclusion: Muscular lipids are substrates for metabolism and can be assessed non-invasively by 1H-MRS. 1H-MRS is considered to be a helpful tool in clinical assessment of muscle metabolism in cases with muscular hypo- or hypertrophy.

참고문헌 (Reference)

1 Goff LM, "Veganism and its relationship with insulin resistance and intramyocellular lipid" 59 : 291-298, 2005

2 Brechtel K, "Utilisation of intramyocellular lipids (IMCLs) during exercise as assessed by proton magnetic resonance spectroscopy (1H-MRS)" 33 : 63-66, 2001

3 Weigert C, "The -913 G/A glutamine: fructose-6-phosphate aminotransferase gene polymorphism is associated with measures of obesity and intramyocellular lipid content in nondiabetic subjects" 90 : 1639-1643, 2005

4 Boesch C, "Role of proton MR for the study of muscle lipid metabolism" 19 : 968-988, 2006

5 Narayana PA, "Proton magnetic resonance spectroscopic studies of hypertrophied muscle. Effect of botulinum toxin treatment" 26 : 58-64, 1991

6 Roden M, "Muscle triglycerides and mito-chondrial function: possible mechanisms for the development of type 2 diabetes" 29 : S111-S115, 2005

7 Maurer J, "Muscle metabolism of professional athletes using 31P-spectroscopy" 40 : 73-77, 1999

8 Szczepaniak LS, "Measurement of intracellular triglyceride stores by 1H spectroscopy: validation in vivo" 276 : E977-E989, 1999

9 Vahlensieck M, "MRI of the musculoskeletal system" Thieme 257-282, 2000

10 Henriksen O, "MR spectroscopy in clinical research" 35 : 96-116, 1994

11 Zehnder M, "Intramyocellular lipid stores increase markedly in athletes after 1.5 days lipid supplementation and are utilized during exercise in proportion to their content" 98 : 341-354, 2006

12 Krssak M, "Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study" 42 : 113-116, 1999

13 Boesch C, "In vivo determination of intra-myocellular lipids in human muscle by means of localized 1H-MR-spectroscopy" 37 : 484-493, 1997

14 Giannesini B, "In vivo MR investigation of skeletal muscle function in small animals" 17 : 210-218, 2004

15 Olsen NJ, "Imaging and skeletal muscle disease" 7 : 106-114, 2005

16 De Beuckeleer L, "Hypertrophy and pseudohypertrophy of the lower leg following chronic radiculopathy and neuropathy: imaging findings in two patients" 28 : 229-232, 1999

17 Vermathen P, "Distribution of intramyocellular lipids in human calf muscles as determined by MR spectroscopic imaging" 51 : 253-262, 2004

18 Petersilge CA, "Denervation hypertrophy of muscle: MR features" 19 : 596-600, 1995

19 Wessig C, "Denervation hypertrophy may mimic local tumor spread on magnetic resonance imaging" 34 : 108-110, 2006

20 Nakae I, "Creatine depletion and altered fatty acid metabolism in diseased human hearts: clinical investigation using 1H magnetic resonance spectroscopy and 123I BMIPP myocardial scintigraphy" 48 : 436-443, 2007

21 Schick F, "Comparison of localized proton NMR signals of skeletal muscle and fat tissue in vivo: two lipid compartments in muscle tissue" 29 : 158-167, 1993

22 Merkli H, "Asymmetric calf hypertrophy of neurogenic origin" 12 : 254-256, 2006

23 Jacob S, "Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects" 48 : 1113-1119, 1999