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      Drug-resistance pattern of Mycobacterium tuberculosis strains from patients with pulmonary and extrapulmonary tuberculosis during 2006 to 2013 in a Korean tertiary medical center

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      https://www.riss.kr/link?id=A103901967

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      Background/Aims: We evaluated the trend in the rates of drug-resistant tuberculosis (TB) over time, as well as the difference in the drug-resistance pattern between pulmonary tuberculosis (PTB) and extrapulmonary tuberculosis (EPTB) at a private referral center in South Korea.
      Methods: All patients with culture-confirmed TB from 2006 to 2013 were included.
      Results: In total, 1,745 patients were included: 1,431 (82.0%) were new cases, and 314 (18.0%) were cases treated previously; 1,610 (92.3%) were diagnosed with PTB, and 135 (7.7%) were diagnosed with EPTB. Multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB were detected in 5.8% and 2.0% of new cases and in 20.1% and 8.6% of previously treated cases, respectively. The MDR TB rate during the study period decreased remarkably, whereas the MDR and XDR TB rates decreased significantly in previously treated cases. No difference in the drug-resistance rate was detected between PTB and EPTB.
      Conclusions: The TB drug-resistance rate, particularly that of MDR TB, remained high at a private referral hospital, and the drug-resistance rate did not decrease significantly from 2006 to 2013. This finding underscores the need for a national survey regarding the prevalence of drug-resistant TB to obtain the most accurate and current drug-resistance status in South Korea, including the private sector.
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      Background/Aims: We evaluated the trend in the rates of drug-resistant tuberculosis (TB) over time, as well as the difference in the drug-resistance pattern between pulmonary tuberculosis (PTB) and extrapulmonary tuberculosis (EPTB) at a private refer...

      Background/Aims: We evaluated the trend in the rates of drug-resistant tuberculosis (TB) over time, as well as the difference in the drug-resistance pattern between pulmonary tuberculosis (PTB) and extrapulmonary tuberculosis (EPTB) at a private referral center in South Korea.
      Methods: All patients with culture-confirmed TB from 2006 to 2013 were included.
      Results: In total, 1,745 patients were included: 1,431 (82.0%) were new cases, and 314 (18.0%) were cases treated previously; 1,610 (92.3%) were diagnosed with PTB, and 135 (7.7%) were diagnosed with EPTB. Multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB were detected in 5.8% and 2.0% of new cases and in 20.1% and 8.6% of previously treated cases, respectively. The MDR TB rate during the study period decreased remarkably, whereas the MDR and XDR TB rates decreased significantly in previously treated cases. No difference in the drug-resistance rate was detected between PTB and EPTB.
      Conclusions: The TB drug-resistance rate, particularly that of MDR TB, remained high at a private referral hospital, and the drug-resistance rate did not decrease significantly from 2006 to 2013. This finding underscores the need for a national survey regarding the prevalence of drug-resistant TB to obtain the most accurate and current drug-resistance status in South Korea, including the private sector.

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      참고문헌 (Reference)

      1 배은신, "항산균 배양에서 BACTEC Mycobacteria Growth Indicator Tube 960 System과 Ogawa 배지 병용의 평가" 대한진단검사의학회 28 (28): 299-306, 2008

      2 김희진, "한국에서의 결핵현황" 대한내과학회 82 (82): 257-262, 2012

      3 윤늘봄, "일개 부산지역 3차 병원에서 관찰한 다제내성 결핵의 실태, 2005∼2009" 대한결핵및호흡기학회 71 (71): 120-125, 2011

      4 김도균, "서울지역 한 대학병원에서 조사된 폐결핵 약제 내성률 및 위험인자" 대한결핵및호흡기학회 58 (58): 243-247, 2005

      5 이동훈, "대전지역 일개 종합병원 초진결핵 환자들로부터 分離된 結核菌의 藥劑 耐性率" 한국산학기술학회 12 (12): 5012-5018, 2011

      6 김선영, "국내 다제내성 및 광범위내성결핵의 최근 현황" 대한결핵및호흡기학회 68 (68): 146-154, 2010

      7 Bai GH, "Trend of anti-tuberculosis drug resistance in Korea, 1994-2004" 11 : 571-576, 2007

      8 World Health Organization, "Treatment of Tuberculosis:Guidelines for National Programmes"

      9 Vishnevskii BI, "The rate and pattern of drug resistance in Mycobacterium tuberculosis at various sites of the disease" 12 : 5-8, 2008

      10 World Health Organization, "The Treatment of Tuberculosis:Guidelines"

      1 배은신, "항산균 배양에서 BACTEC Mycobacteria Growth Indicator Tube 960 System과 Ogawa 배지 병용의 평가" 대한진단검사의학회 28 (28): 299-306, 2008

      2 김희진, "한국에서의 결핵현황" 대한내과학회 82 (82): 257-262, 2012

      3 윤늘봄, "일개 부산지역 3차 병원에서 관찰한 다제내성 결핵의 실태, 2005∼2009" 대한결핵및호흡기학회 71 (71): 120-125, 2011

      4 김도균, "서울지역 한 대학병원에서 조사된 폐결핵 약제 내성률 및 위험인자" 대한결핵및호흡기학회 58 (58): 243-247, 2005

      5 이동훈, "대전지역 일개 종합병원 초진결핵 환자들로부터 分離된 結核菌의 藥劑 耐性率" 한국산학기술학회 12 (12): 5012-5018, 2011

      6 김선영, "국내 다제내성 및 광범위내성결핵의 최근 현황" 대한결핵및호흡기학회 68 (68): 146-154, 2010

      7 Bai GH, "Trend of anti-tuberculosis drug resistance in Korea, 1994-2004" 11 : 571-576, 2007

      8 World Health Organization, "Treatment of Tuberculosis:Guidelines for National Programmes"

      9 Vishnevskii BI, "The rate and pattern of drug resistance in Mycobacterium tuberculosis at various sites of the disease" 12 : 5-8, 2008

      10 World Health Organization, "The Treatment of Tuberculosis:Guidelines"

      11 Yoon-Sung Park, "The National Status of Tuberculosis Using Nationwide Medical Records Survey of Patients with Tuberculosis in Korea" 대한결핵및호흡기학회 73 (73): 48-55, 2012

      12 Caminero JA., "Multidrug-resistant tuberculosis: epidemiology, risk factors and case finding" 14 : 382-390, 2010

      13 Gandhi NR, "Multidrug-resistant and extensively drug-resistant tuberculosis: a threat to global control of tuberculosis" 375 : 1830-1843, 2010

      14 이세원, "Multidrug-resistant Pulmonary Tuberculosis Among Young Korean Soldiers in a Communal Setting" 대한의학회 24 (24): 592-595, 2009

      15 박영길, "Increased Tuberculosis Burden Due to Demographic Transition in Korea from 2001 to 2010" 대한결핵및호흡기학회 74 (74): 104-110, 2013

      16 Korea Centers for Disease Control and Prevention, "Guidelines for National Tuberculosis Control"

      17 World Health Organization, "Global tuberculosis Control:Surveillance, Planning, financing: WHO Report 2010" World Health Organization 2010

      18 Peto HM, "Epidemiology of extrapulmonary tuberculosis in the United States, 1993-2006" 49 : 1350-1357, 2009

      19 최재철, "Drug Resistance Rates of Mycobacterium tuberculosis at a PrivateReferral Center in Korea" 대한의학회 22 (22): 677-681, 2007

      20 Lai CC, "Differences in drug resistance profiles of Mycobacterium tuberculosis isolates causing pulmonary and extrapulmonary tuberculosis in a medical centre in Taiwan, 2000-2010" 38 : 125-129, 2011

      21 Korea Centers for Disease Control and Prevention, "Annual Report on the Notified Tuberculosis in Korea" Korea Centers for Disease Control and Prevention 2012

      22 박영길, "2003~2005년도 민간 병의원 신환자에서 분리된 결핵균의 항결핵약제 내성률" 대한결핵및호흡기학회 64 (64): 87-94, 2008

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      학술지 이력

      학술지 이력
      연월일 이력구분 이력상세 등재구분
      2023 평가예정 해외DB학술지평가 신청대상 (해외등재 학술지 평가)
      2020-01-01 평가 등재학술지 유지 (해외등재 학술지 평가) KCI등재
      2011-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2008-01-01 평가 등재학술지 선정 (등재후보2차) KCI등재
      2007-01-01 평가 등재후보 1차 PASS (등재후보1차) KCI등재후보
      2005-01-01 평가 등재후보학술지 선정 (신규평가) KCI등재후보
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      학술지 인용정보

      학술지 인용정보
      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 1.37 0.26 1.02
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      0.83 0.73 0.566 0.13
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