기분장애 뇌신경기저에 대한 이해 : 뇌영상 연구를 중심으로 = Understanding of Neural Mechanism of Mood Disorders : Focused on Neuroimaging Findings

다국어 초록 (Multilingual Abstract)

Mood disorder is unlikely to be a disease of a single brain region or a neurotransmitter system. Rather, it is now generally viewed as a multidimensional disorder that affects many neural pathways. Growing neuroimaging evidence suggests the anterior cingulate-pallidostriatal-thalamic-amygdala circuit as a putative cortico-limbic mood regulating circuit that may be dysfunctional in mood disorders. Brain-imaging techniques have shown increased activation of mood-generating limbic areas and decreased activation of cortical areas in major depressive disorder(MDD). Furthermore, the combination of functional abnormalities in limbic subcortical neural regions implicated in emotion processing together with functional abnormalities of prefrontal cortical neural regions probably result in the emotional lability and impaired ability to regulate emotion in bipolar disorder. Here we review the biological correlates of MDD and bipolar disorder as evidenced by neuroimaging paradigms, and interpret these data from the perspective of endophenotype. Despite possible limitations, we believe that the integration of neuroimaging research findings will significantly advance our understanding of affective neuroscience and provide novel insights into mood disorders.

참고문헌 (Reference)

1 Yurgelun-Todd DA, "fMRI during affect discrimination in bipolar affective disorder" 2 : 237-248, 2000

2 Holsboer F, "Unipolar versus bipolar disorder: a distinction not helpful for studies of causality" 7 : 405-407, 2005

3 Keller MB, "Time to recovery, chronicity, and levels of psychopathology in major depression. A 5- year prospective follow-up of 431 subjects" 49 : 809-816, 1992

4 Keyes CL, "The structure of the genetic and environmental influences on mental wellbeing" 100 : 2379-2384,

5 Ohman A, "The role of the amygdala in human fear: automatic detection of threat" 30 : 953-958, 2005

6 Post RM, "The role of psychosocial stress in the onset and progression of bipolar disorder and its comorbidities: the need for earlier and alternative modes of therapeutic intervention" 18 : 1181-1211, 2006

7 Keedwell PA, "The neural correlates of anhedonia in major depressive disorder" 58 : 843-853, 2005

8 Goldin PR, "The neural bases of emotion regulation: reappraisal and suppression of negative emotion" 63 : 577-586, 2008

9 Rice F, "The genetic aetiology of childhood depression: a review" 43 : 65-79, 2002

10 Gottesman II, "The endophenotype concept in psychiatry: etymology and strategic intentions" 160 : 636-645, 2003

11 Cloninger CR, "The discovery of susceptibility genes for mental disorders" 99 : 13365-13367, 2002

12 Ochsner KN, "The cognitive control of emotion" 9 : 242-249, 2005

13 Drevets WC, "Subgenual prefrontal cortex abnormalities in mood disorders" 386 : 824-827, 1997

14 Keedwell PA, "Subgenual cingulate and visual cortex responses to sad faces predict clinical outcome during antidepressant treatment for depression" 120 : 120-125,

15 Lawrence NS, "Subcortical and ventral prefrontal cortical neural responses to facial expressions distinguish patients with bipolar disorder and major depression" 55 : 578-587, 2004

16 Schwartz CE, "Structural differences in adult orbital and ventromedial prefrontal cortex predicted by infant temperament at 4 months of age" 67 : 78-84,

17 Amico F, "Structural MRI correlates for vulnerability and resilience to major depressive disorder" 36 : 15-22,

18 Kronhaus DM, "Stroop performance in bipolar disorder: further evidence for abnormalities in the ventral prefrontal cortex" 8 : 28-39, 2006

19 Papadakis AA, "Selfregulation, rumination, and vulnerability to depression in adolescent girls" 18 : 815-829, 2006

20 Chan SW, "Risk for depression and neural responses to fearful facial expressions of emotion" 194 : 139-145, 2009

21 Kruger S, "Risk and resilience markers in bipolar disorder: brain responses to emotional challenge in bipolar patients and their healthy siblings" 163 : 257-264, 2006

22 Forbes EE, "Reward-related decision- making in pediatric major depressive disorder: an fMRI study" 47 : 1031-1040, 2006

23 Mayberg HS, "Regional metabolic effects of fluoxetine in major depression: serial changes and relationship to clinical response" 48 : 830-843, 2000

24 Mah L, "Regional cerebral glucose metabolic abnormalities in bipolar II depression" 61 : 765-775, 2007

25 Bench CJ, "Regional cerebral blood flow in depression measured by positron emission tomography: the relationship with clinical dimensions" 23 : 579-590, 1993

26 van Harmelen AL, "Reduced medial prefrontal cortex volume in adults reporting childhood emotional maltreatment" 68 : 68-,

27 Malhi GS, "Reduced activation to implicit affect induction in euthymic bipolar patients: an fMRI study" 97 : 109-122, 2007

28 Phillips ML, "Redefining bipolar disorder: toward DSM-V" 163 : 1135-1136, 2006

29 Hirschfeld RM, "Recognition and diagnosis of bipolar disorder" 65 (65): 5-9, 2004

30 Coffey CE, "Quantitative cerebral anatomy in depression. A controlled magnetic resonance imaging study" 50 : 7-16, 1993

31 Mervaala E, "Quantitative MRI of the hippocampus and amygdala in severe depression" 30 : 117-125, 2000

32 Greenwald BS, "Qualitative magnetic resonance imaging findings in geriatric depression. Possible link between later-onset depression and Alzheimer’s disease" 27 : 421-431, 1997

33 Pietrzak RH, "Psychosocial buffers of traumatic stress, depressive symptoms, and psychosocial difficulties in veterans of Operations Enduring Freedom and Iraqi Freedom: the role of resilience, unit support, and postdeployment social support" 9 : 74-78, 2009

34 Gong Q, "Prognostic prediction of therapeutic response in depression using high-field MR imaging" Neuroimage

35 Kessler RC, "Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication" 62 : 617-627, 2005

36 Elliott R, "Prefrontal dysfunction in depressed patients performing a complex planning task: a study using positron emission tomography" 27 : 931-942, 1997

37 Nolan CL, "Prefrontal cortical volume in childhood- onset major depression: preliminary findings" 59 : 173-179, 2002

38 Goodman M, "Phenotype, endophenotype, and genotype comparisons between borderline personality disorder and major depressive disorder" 24 : 38-59,

39 Hirschfeld RM, "Perceptions and impact of bipolar disorder: how far have we really come? Results of the national depressive and manic-depressive association 2000 survey of individuals with bipolar disorder" 64 : 161-174, 2003

40 Weinberger MI, "Perceived barriers to mental health care and goal setting among depressed, community-dwelling older adults" 3 : 145-149, 2009

41 Cremers HR, "Neuroticism modulates amygdala-prefrontal connectivity in response to negative emotional facial expressions" 49 : 963-970,

42 Keener MT, "Neuroimaging in bipolar disorder: a critical review of current findings" 9 : 512-520, 2007

43 Phillips ML, "Neurobiology of emotion perception I: The neural basis of normal emotion perception" 54 : 504-514, 2003

44 Phillips ML, "Neurobi ology of emotion perception II: Implications for major psychiatric disorders" 54 : 515-528, 2003

45 Gotlib IH, "Neural processing of reward and loss in girls at risk for major depression" 67 : 380-387,

46 Ritchey M, "Neural correlates of emotional processing in depression: Changes with cognitive behavioral therapy and predictors of treatment response"

47 Chakravarti A, "Nature, nurture and human disease" 421 : 412-414, 2003

48 Rajkowska G, "Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression" 45 : 1085-1098, 1999

49 Herbsman T, "More lateral and anterior prefrontal coil location is associated with better repetitive transcranial magnetic stimulation antidepressant response" 66 : 509-515, 2009

50 Farb NA, "Minding one’s emotions: mindfulness training alters the neural expression of sadness" 10 : 25-33,

51 Hammen C, "Longitudinal study of diagnoses in children of women with unipolar and bipolar affective disorder" 47 : 1112-1117, 1990

52 Carmichael ST, "Limbic connections of the orbital and medial prefrontal cortex in macaque monkeys" 363 : 615-641, 1995

53 Merikangas KR, "Lifetime and 12- month prevalence of bipolar spectrum disorder in the National Comorbidity Survey replication" 64 : 543-552, 2007

54 Van der Schot A, "Kahn R, Ramsey N, Nolen W, Vink M. Trait and state dependent functional impairments in bipolar disorder" 184 : 135-142,

55 Hahn T, "Integrating Neurobiological Markers of Depression" Arch Gen Psychiatry

56 Siegle GJ, "Increased amygdala and decreased dorsolateral prefrontal BOLD responses in unipolar depression: related and independent features" 61 : 198-209, 2007

57 Altshuler L, "Increased amygdala activation during mania: a functional magnetic resonance imaging study" 162 : 1211-1213, 2005

58 Illes J, "In the mind’s eye: provider and patient attitudes on functional brain imaging" 43 : 107-114, 2008

59 Cabeza R, "Imaging cognition II: An empirical review of 275 PET and fMRI studies" 12 : 1-47, 2000

60 Admon R, "Human vulnerability to stress depends on amygdala’s predisposition and hippocampal plasticity" 106 : 14120-14125, 2009

61 Bremner JD, "Hippocampal volume reduction in major depression" 157 : 115-118, 2000

62 Baare WF, "Hippocampal volume changes in healthy subjects at risk of unipolar depression" 44 : 655-662,

63 Rice F, "Genetics of childhood and adolescent depression: insights into etiological heterogeneity and challenges for future genomic research" 2 (2):

64 Robinson JL, "Fronto-limbic circuitry in euthymic bipolar disorder: evidence for prefrontal hyperactivation" 164 : 106-113, 2008

65 Gorno-Tempini ML, "Explicit and incidental facial expression processing: an fMRI study" 14 : 465-473, 2001

66 Chen CH, "Explicit and implicit facial affect recognition in manic and depressed States of bipolar disorder: a functional magnetic resonance imaging study" 59 : 31-39, 2006

67 Vasic N, "Executive functions in pa-tients with depression. The role of prefrontal activation" 78 (78): 630-626, 2007

68 Schaefer HS, "Event-related functional magnetic resonance imaging measures of neural activity to positive social stimuli in pre- and post-treatment depression" 60 : 974-986, 2006

69 Sabatinelli D, "Emotional perception: Meta-analyses of face and natural scene processing"

70 Hassel S, "Elevated striatal and decreased dorsolateral prefrontal cortical activity in response to emotional stimuli in euthymic bipolar disorder: no associations with psychotropic medication load" 10 : 916-927, 2008

71 Ketter TA, "Effects of mood and subtype on cerebral glucose metabolism in treatment-resistant bipolar disorder" 49 : 97-109, 2001

72 van der Veen FM, "Effects of acute tryptophan depletion on mood and facial emotion perception related brain activation and performance in healthy women with and without a family history of depression" 32 : 216-224, 2007

73 Fortier E, "Early impact of 5-HTTLPR polymorphism on the neural correlates of sadness" 485 : 261-265,

74 Wagner G, "Differential effects of serotonergic and noradrenergic antidepressants on brain activity during a cognitive control task and neurofunctional prediction of treatment outcome in patients with depression" 35 : 247-257,

75 Davidson RJ, "Depression: perspectives from affective neuroscience" 53 : 545-574, 2002

76 Liu Z, "Decreased regional homogeneity in insula and cerebellum: a resting-state fMRI study in patients with major depression and subjects at high risk for major depression" 182 : 211-215,

77 Chen MC, "Decreased hippocampal volume in healthy girls at risk of depression" 67 : 270-276,

78 Matthews SC, "Decreased functional coupling of the amygdala and supragenual cingulate is related to increased depression in unmedicated individuals with current major depressive disorder" 111 : 13-20, 2008

79 Shah PJ, "Cortical grey matter reductions associated with treatmentresistant chronic unipolar depression. Controlled magnetic resonance imaging study" 172 : 527-532, 1998

80 Winston JS, "Common and distinct neural responses during direct and incidental processing of multiple facial emotions" 20 : 84-97, 2003

81 Malhi GS, "Cognitive generation of affect in hypomania: an fMRI study" 6 : 271-285, 2004

82 Lazarus RS, "Cognition and motivation in emotion" 46 : 352-367, 1991

83 Vythilingam M, "Childhood trauma associated with smaller hippocampal volume in women with major depression" 159 : 2072-2080, 2002

84 Chen CH, "Brain imaging correlates of depressive symptom severity and predictors of symptom improvement after antidepressant treatment" 62 : 407-414, 2007

85 Henry TR, "Brain blood flow alterations induced by therapeutic vagus nerve stimulation in partial epilepsy: I. Acute effects at high and low levels of stimulation" 39 : 983-990, 1998

86 Altshuler LL, "Blunted activation in orbitofrontal cortex during mania: a functional magnetic resonance imaging study" 58 : 763-769, 2005

87 Lennox BR, "Behavioural and neurocognitive responses to sad facial affect are attenuated in patients with mania" 34 : 795-802, 2004

88 Spijker J, "Are the vulnerability effects of personality and psychosocial functioning on depression accounted for by subthreshold symptoms" 24 : 472-478, 2007

89 Anand A, "Antidepressant effect on connectivity of the mood-regulating circuit: an FMRI study" 30 : 1334-1344, 2005

90 Pavuluri MN, "An fMRI study of the neural correlates of incidental versus directed emotion processing in pediatric bipolar disorder" 48 : 308-319, 2009

91 Canli T, "An fMRI study of personality influences on brain reactivity to emotional stimuli" 115 : 33-42, 2001

92 Caligiuri MP, "An fMRI study of affective state and medication on cortical and subcortical brain regions during motor performance in bipolar disorder" 123 : 171-182, 2003

93 Backs-Dermott BJ, "An evaluation of an integrated model of relapse in depression" 124 : 60-67,

94 Sheline YI, "Amygdala core nuclei volumes are decreased in recurrent major depression" 9 : 2023-2028, 1998

95 Erk S, "Acute and sustained effects of cognitive emotion regulation in major depression" 30 : 15726-15734,

96 Killgore WD, "Abnormal corticostriatal activity during fear perception in bipolar disorder" 19 : 1523-1527, 2008

97 Kendler KS, "A population-based twin study of lifetime major depression in men and women" 56 : 39-44, 1999

98 Phillips ML, "A neural model of voluntary and automatic emotion regulation: implications for understanding the pathophysiology and neurodevelopment of bipolar disorder" 13 (13): 833-857, 2008

99 Gatt JM, "A genotype-endophenotypephenotype path model of depressed mood: integrating cognitive and emotional markers" 6 : 75-104, 2007

100 Liu X, "A genome-wide association study of amygdala activation in youths with and without bipolar disorder" 49 : 33-41,

101 Lagopoulos J, "A functional magnetic resonance imaging study of emotional Stroop in euthymic bipolar disorder" 18 : 1583-1587, 2007