제2수지-제4수지 길이 비율과 대뇌 편측화 관계 연구 = A Study of the Relationships between the Ratio of $2^{nd}$ to $4^{th}$ Digit Length and Cerebral Laterality

다국어 초록 (Multilingual Abstract)

Objectives : Cerebral laterality is thought to be an important marker for neurodevelopment. Prenatal testosterone could influence both cerebral laterality and 2nd to 4th finger length ratio(2D : 4D). EEG coherence and 2D : 4D were examined to investigate the relationship between prenatal testosterone level and cerebral laterality. Methods : EEG was recorded in 24 healthy subjects in the eyes closed resting state. Differences in 2D : 4D finger ratio were used to discriminate "masculine finger type" and "feminine finger type" groups. The 2D : 4D ratio was lower and greater than one for the "masculine finger type" group and "feminine finger type" group, respectively. We used coherence analysis to estimate the cortical functional connectivity. Results : There were statistically meaningful relationships among cerebral functional connectivity, sex and finger ratio. Man and masculine finger type group showed higher intra-hemispheric coherence than those of woman and feminine finger type group. Woman and feminine finger type group showed higher inter-hemispheric coherence than those of man and masculine finger type group. Conclusions : These results imply that prenatal testosterone might act as important determinants of cerebral laterality. Further examination of the relationship between 2D : 4D and EEG coherence in schizophrenia could give some clues for the neurodevelopmental hypothesis of schizophrenia genesis.

참고문헌 (Reference)

1 조현우, "정신분열병 환자와 정상 대조군 간의 검지-약지 길이 비의 차이" 대한신경정신의학회 48 (48): 495-500, 2009

2 신아영, "여자 국가대표 선수의 검지-약지 비와 공격성 연관 종목 특징의 관계" 대한생물정신의학회 17 (17): 37-43, 2010

3 곽용태, "알쯔하이머병에서 뇌파 Coherence" 대한신경과학회 21 (21): 163-168, 2003

4 최경호, "손가락 길이 비율(2D : 4D)의 성차" 한국발육발달학회 15 (15): 155-159, 2007

5 김혜진, "검지 - 약지 길이 비와 공감, 공격성, 성역할 정체감간의 관련성" 대한신경정신의학회 49 (49): 210-216, 2010

6 Kwak YT, "Usefulness of occipital EEG spectral profile in the differential diagnosis of Alzheimer type and vascular dementia" 18 : 292-297, 2000

7 Sanders G, "The ratio of the 2nd to 4th finger length predicts spatial ability in men but not women" 41 : 789-795, 2005

8 Manning JT, "The ratio of 2nd to 4th digit length and performance in skiing" 42 : 446-450, 2002

9 Rapoport JL, "The neurodevelopmental model of schizophrenia: update 2005" 10 : 434-449, 2005

10 Chamberlain NL, "The length and location of CAG trinucleotide repeats in the androgen receptor N-terminal domain affect transactivation function" 22 : 3181-3186, 1994

11 Manning JT, "The effects of sex, ethnity, and sexual orientation on self-measured figit ratio( 2d：4d)" 36 : 223-233, 2007

12 Oldfield RC, "The assessment and analysis of handedness: the Edinburgh inventory" 9 : 97-113, 1971

13 Simon Baron-Cohen, "The Essential Difference" Brockman, Inc 2003

14 Shaw JC, "The EEG as a measure of cerebral functional organization" 130 : 260-264, 1977

15 van Anders SM, "Testing the prenatal androgen hypothesis: Measuring digit ratios, sexual orientation, and spatial abilities in adults" 47 : 92-98, 2005

16 Csatho A, "Sex role identity related to the ratio of second to fourth digit length in women" 62 : 147-156, 2003

17 Putz DA, "Sex hormones and finger length: What does 2D：4D indicate" 25 : 182-199, 2004

18 Becker JB, "Sex differences in the brain from genes to behavior" Oxford University Press; 2008

19 Azari NP, "Sex differences in patterns of hemispheric cerebral metabolism: a multiple regression/ discriminant analysis of positron emission tomographic date" 81 : 1-20, 1995

20 Marosi E, "Sex differences in EEG coherence in normal children" 72 : 115-121, 1993

21 Volf NV, "Sex difference in EEG coherence during a verbal memory task in normal adults" 34 : 113-122, 1999

22 Manning JT, "Sex and ethnic differences in 2nd to 4th digit ratio of childen" 80 : 161-168, 2004

23 Fink B, "Second to fourth digit ratio and numerical competence in children" 61 : 211-218, 2006

24 Manning JT, "Second to fourth digit ratio and male ability in sport: Implications for sexual selection in humans" 22 : 61-69, 2001

25 Fink B, "Second to fourth digit ratio and face shape. Proceedings-Royal Society" 1995-2001, 2005

26 Hampson E, "On the relation between2d：4d and sex-dimorphic personality traits" 37 : 133-144, 2008

27 Kondo T, "Of fingers, toes and penises" 390 : 185-198, 1997

28 Toga AW, "Mapping brain asymmetry. Nature Reviews" 4 : 37-48, 2003

29 Alter M, "Is hyperploidy of sex chromosomes associated with reduced total finger ridge count" 17 : 473-475, 1965

30 Wada Y, "Interhemispheric EEG coherence during photic stimulation: sex differences in normal young adults" 22 : 45-51, 1996

31 Petronis A, "Human morbid genetics revisited: relevance of epigenetics" 17 : 142-146, 2001

32 Davis, AE, "Hemispheric asymmetry: frequen cy analysis of visual and auditory evoked responses to non verbal stimuli" 37 : 1-9, 1974

33 Gobrogge KL, "Genetic and environmental influences on 2D：4D finger length ratios: a study of monozygotic and dizygotic male and female twins" 37 : 112-118, 2008

34 Wada Y, "Gender differences in quantitative EEG at rest and during photic stimulation in normal young adults" 25 : 81-85, 1994

35 Azari NP, "Gender differences in correlations of cerebral glucose metabolism rates in young normal adults" 574 : 198-208, 1992

36 Bailey AA, "Finger length ratio(2d：4d) correlates with physical aggression in men not in women" 68 : 215-222, 2005

37 Kraemer B, "Finger length ratio(2d：4d) and dimensions of sexual orientation" 53 : 210-214, 2006

38 Guevara MA, "EEG coherence or EEG correlation" 23 : 145-153, 1996

39 Adler G, "EEG coherence in Alzheimer’s dementia" 110 : 1051-1058, 2003

40 Jaus˘ovec N, "EEG activity during the performance of complex mental problems" 36 : 73-88, 2000

41 Manning JT, "Digit ratio: A pointer to fertility, behavior, and health. New Brunswick" Rutgers University Press 2002

42 Benderlioglu Z, "Digit length ratios predict reactive aggression in women, but not in men" 46 : 558-564, 2004

43 Arato M, "Digit length pattern in schizophrenia suggests disturbed prenatal hemispheric lateralization" 28 : 191-194, 2004

44 Thatcher RW, "Cortico-cortical associations and EEG coherence: a two-compartmental model" 64 : 123-143, 1986

45 Geschwind N, "Cerebral lateralization: Biological mechanisms, associations, and pathology: I.II. III. A hypothesis and a program for research. Archives of Neurology" 42 : 428-654, 1985

46 Wood FB, "Cerebral laterality in functional neuroimaging. Cerebral Laterality: Theory and Research" 103-115,

47 Beaumont GJ, "Asymmetry in EEG alpha coherence and power: effects of task and sex" 45 : 393-401, 1978

48 Kawasaki Y, "Anomalous cerebral asymmetry in patients with schizophrenia demonstrated by voxel- based morphometry" 63 : 793-800, 2008

49 Amanda EG, "Amygdala and Ventrolateral Prefrontal Cortex Function During Anticipated Peer Evaluation in Pediatric Social Anxiety" 65 : 1303-1312, 2008