검열반과 익상편 환자에서 눈물막과 안구표면의 변화 = Changes of Ocular Surface and Tear Film in Patients with Pinguecula and Pterygium

다국어 초록 (Multilingual Abstract)

Purpose: This study was performed to evaluate the parameters of tear function and ocular surface in patients with pinguecula and pterygium. Methods: The corneal sensitivity test (CST), tear break-up time (BUT), basal tear secretion test, fluorescein staining, rose bengal staining, tear clearance test, and conjunctival impression cytology were evaluated in patients with unilateral pinguecula and pterygium. The results were also evaluated according to the severity of pterygium. Results: In patients with pinguecula, BUT (P=0.03) and goblet cell density (P<0.01) were decreased, while the rose bengal staining score (P=0.01) was increased significantly. In patients with pterygium, CST (P=0.01), BUT (P<0.01), and goblet cell density (P<0.01) decreased, and the fluorescein staining score (P<0.01), rose bengal staining score (P<0.01) and grade of conjunctival metaplasia (P<0.01) increased significantly. In comparison with mild pterygium, moderate pterygium demonstrated decreased CST (P=0.01) and BUT (P=0.01), and an increased rose bengal staining score (P=0.04). Conclusions: The tear films and ocular surface changes in patients with pinguecula and pterygium are worse than in control group. Also, there is close correlation between the severity of pterygium and dry eye condition.

참고문헌 (Reference)

1 "The tear film complex pathogenesis and emerging therapies for dry eyes" 24 : 1-7, 2005

2 "The significance of the goblet cell count in the diagnosis of dry eye syndrome" 31 : 845-9, 1990

3 "The pathogenesis of pterygia" 10 : 282-288, 1999

4 "The effect of punctal plug on dry eye syndrome" 35 : 737-44, 1994

5 "Tear function in patients with pterygium" 76 : 176-179, 1998

6 "Tear function in patients with pinguecula" 79 : 262-265, 2001

7 "Tear dynamics and dry eye" 17 : 565-596, 1998

8 "Subthreshold UV radiation-induced peroxide formation in cultured corneal epithelial cells:The protective effect of lactoferrin" 63 : 519-526, 1995

9 "Study on tear function abnormality in pterygium" 215 : 204-208, 2001

10 "Study of mucin of tear film in patients with pterygium" 105 : 60-62, 2003

11 "Staining of conjunctival squamous metaplasia by impression cytology" 92 : 728-33, 1985

12 "Punctal occlusion for Stevens-Johnson syndrome" 111 : 895-900, 2004

13 "Pterygium as an early indicator of ultraviolet insolation" 77 : 734-9, 1993

14 "Pterygium and its relationship to the dry eye in the Bantu" 60 : 720-1, 1976

15 "Pterygium and dry eye- A clinical correlation" 38 : 15-6, 1991

16 "Pterygium and basic tear secretion" 11 : 1235-6, 1979

17 "Pterygium and Dry eye" 215 : 209-211, 2001

18 "Pinguecula and pterigia" 32 : 41-9, 1988

19 "Physical chemistry of the normal and disordered tear film" 374-380,

20 "Pathogenesis of pterygia:role of cytokines,growth factor,and matrix metalloproteinase" 23 : 195-228, 2004

21 "P53 expression in altered limbal basal cells of pingueculae,pterygia,and limbal tumor" 16 : 1179-1192, 1997

22 "Ocular surface change in keratoconjunctivitis sicca with silicone punctum plug occlusion" 26 : 263-269, 2003

23 "Ocular surface change in Pterygium" 21 : 38-42, 2002

24 "Lactoferin in human ocular tissues" 90 : 30-7, 1980

25 "Impression cytology of Pterygium" 16 : 519-528, 2000

26 "Impression cytology for the detection of vitamin A deficiency" 105 : 1224-8, 1987

27 "Impression cytology" 7 : 71-81, 1988

28 "Immunological studies on the pathogenesis of pterygium" 8 : 84-8, 1993

29 "Immunohistochemical localization of basic fibroblast growth factor,platelet derived growth factor,transforming growth factor- and TNF- in the pterygium" 98 : 195-201, 1996

30 "Evaluation of the ocular surface in dry-eye conditions" 34 : 57-69, 1980

31 "Evaluation of loss of heterozygosity and microsatellite instability in human pterygium:clinical correlation" 82 : 1324-1328, 1998

32 "Diagnostic tests in the sicca syndrome Arch Ophthalmol 1985"

33 "Detection of human papillomavirus DNA in pterygia from different geographical lesions" 87 : 864-866, 2003

34 "Decreased in corneal sensitivity and change in tear fucntion in dry eye" 15 : 235-239, 1996

35 "Correaltion of the schirmer 1 and fluorescein cleranace test with the severity of corenal epithelial and eyelid disease" 12 : 1632-1638, 2000

36 "Conjunctival cytologic feature of primary Sjogren's syndrome" 97 : 985-91, 1990

37 "Changes in the tear film and ocular surface from dry eye syndrome" 23 : 449-474, 2004

38 "Apoptosis in UV-exposure rabbit corneas" 19 : 99-103, 2000

39 "A Clinical Study of the Pinguecula" 21 : 35-41, 1980