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      KCI등재 SCOPUS

      유기인산염 살충제 중독의 해독제:atropine과 pralidoxime = Antidote for organophosphate insecticide poisoning:atropine and pralidoxime

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      https://www.riss.kr/link?id=A104795945

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      다국어 초록 (Multilingual Abstract)

      Acute organophosphate (OP) poisoning produces cholinergic symptoms resulting from the inhibition of cholinesterase, and the overstimulation of muscarinic and nicotinic receptors in the synapses. The dominant clinical features of acute cholinergic toxicity include bradycardia,miosis, lacrimation, salivation, bronchorrhea, and bronchospasm. All symptomatic patients should receive therapy with oxygen, atropine, and pralidoxime. Atropine works as a physiologic antidote by competitively occupying muscarinic receptor sites, reducing the effects of excessive acetylcholine. Atropine should be immediately administered, and the dose can be titrated according to the severity of OP poisoning. A large dose may be necessary to overcome the excessive cholinergic state in case of severe poisoning. Pralidoxime is a biochemical antidote that reactivates acetylcholinesterase by removing OP from it. It is effective in treating both muscarinic and nicotinic symptoms. After some period of time, the acetylcholinesterase-OP compound undergoes a conformational change, known as aging, which renders the enzyme irreversibly resistant to reactivation by a pralidoxime. There has been a great deal of controversy over the effectiveness of pralidoxime in acute OP poisoning. However, it may be beneficial to administer pralidoxime for a sufficient period in case of severe poisoning with a large quantity of OP,which is common in Korea.
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      Acute organophosphate (OP) poisoning produces cholinergic symptoms resulting from the inhibition of cholinesterase, and the overstimulation of muscarinic and nicotinic receptors in the synapses. The dominant clinical features of acute cholinergic toxi...

      Acute organophosphate (OP) poisoning produces cholinergic symptoms resulting from the inhibition of cholinesterase, and the overstimulation of muscarinic and nicotinic receptors in the synapses. The dominant clinical features of acute cholinergic toxicity include bradycardia,miosis, lacrimation, salivation, bronchorrhea, and bronchospasm. All symptomatic patients should receive therapy with oxygen, atropine, and pralidoxime. Atropine works as a physiologic antidote by competitively occupying muscarinic receptor sites, reducing the effects of excessive acetylcholine. Atropine should be immediately administered, and the dose can be titrated according to the severity of OP poisoning. A large dose may be necessary to overcome the excessive cholinergic state in case of severe poisoning. Pralidoxime is a biochemical antidote that reactivates acetylcholinesterase by removing OP from it. It is effective in treating both muscarinic and nicotinic symptoms. After some period of time, the acetylcholinesterase-OP compound undergoes a conformational change, known as aging, which renders the enzyme irreversibly resistant to reactivation by a pralidoxime. There has been a great deal of controversy over the effectiveness of pralidoxime in acute OP poisoning. However, it may be beneficial to administer pralidoxime for a sufficient period in case of severe poisoning with a large quantity of OP,which is common in Korea.

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      참고문헌 (Reference)

      1 박준홍, "약물 중독 환자에게 아트로핀 사용 후 나타나는 정신증에 대한 분석" 대한응급의학회 17 (17): 336-343, 2006

      2 오민혜, "급성 유기인산염 중독환자에서 Atracurium을 사용한 전신마취 경험" 대한마취통증의학회 51 (51): 233-235, 2006

      3 Holstege CP, "nsecticides" 6 : 17-23, 2004

      4 Lotti M, "Treatment of acute organophosphate poisoning: evidence of a direct effect on central nervous system by 2-PAM (pyridine-2-aldoxime methyl chloride)" 19 : 121-127, 1982

      5 Eyer P., "The role of oximes in the management of organophosphorus pesticide poisoning" 22 : 165-190, 2003

      6 Harris LW, "The relationship between oxime-induced reactivation of carbamylated acetylcholinesterase and antidotal efficacy against carbamate intoxication" 98 : 128-133, 1989

      7 Sahin I, "The prevalence of pancreatitis in organophosphate poisonings" 21 : 175-177, 2002

      8 Davison AN, "Return of cholinesterase activity in the rat after inhibition by organophosphorus compounds. I. Diethyl p-nitrophenyl phosphate (E 600, paraoxon)" 54 : 583-590, 1953

      9 Worek F, "Reappraisal of indications and limitations of oxime therapy in organophosphate poisoning" 16 : 466-472, 1997

      10 Kozak RJ, "Rapid atropine synthesis for the treatment of massive nerve agent exposure" 41 : 685-688, 2003

      1 박준홍, "약물 중독 환자에게 아트로핀 사용 후 나타나는 정신증에 대한 분석" 대한응급의학회 17 (17): 336-343, 2006

      2 오민혜, "급성 유기인산염 중독환자에서 Atracurium을 사용한 전신마취 경험" 대한마취통증의학회 51 (51): 233-235, 2006

      3 Holstege CP, "nsecticides" 6 : 17-23, 2004

      4 Lotti M, "Treatment of acute organophosphate poisoning: evidence of a direct effect on central nervous system by 2-PAM (pyridine-2-aldoxime methyl chloride)" 19 : 121-127, 1982

      5 Eyer P., "The role of oximes in the management of organophosphorus pesticide poisoning" 22 : 165-190, 2003

      6 Harris LW, "The relationship between oxime-induced reactivation of carbamylated acetylcholinesterase and antidotal efficacy against carbamate intoxication" 98 : 128-133, 1989

      7 Sahin I, "The prevalence of pancreatitis in organophosphate poisonings" 21 : 175-177, 2002

      8 Davison AN, "Return of cholinesterase activity in the rat after inhibition by organophosphorus compounds. I. Diethyl p-nitrophenyl phosphate (E 600, paraoxon)" 54 : 583-590, 1953

      9 Worek F, "Reappraisal of indications and limitations of oxime therapy in organophosphate poisoning" 16 : 466-472, 1997

      10 Kozak RJ, "Rapid atropine synthesis for the treatment of massive nerve agent exposure" 41 : 685-688, 2003

      11 Merrill DG, "Prolonged toxicity of organophosphate poisoning" 10 : 550-551, 1982

      12 Borowitz SM, "Prolonged organophosphate toxicity in a twenty- six-month-old child" 112 : 302-304, 1988

      13 Chang P, "Pressor action of pyridine-2-aldoxime in malathion poisoning" 5 : 125-130, 1978

      14 Sakurada K, "Pralidoxime iodide (2-pAM) penetrates across the blood-brain barrier" 28 : 1401-1407, 2003

      15 Eddleston M, "Pralidoxime in acute organophosphorus insecticide poisoning: a randomised controlled trial" 6 : 1000104-, 2009

      16 Namba T, "Poisoning due to organophosphate insecticides. Acute and chronic manifestations" 50 : 475-492, 1971

      17 Medicis JJ, "Pharmacokinetics following a loading plus a continuous infusion of pralidoxime compared with the traditional short infusion regimen in human volunteers" 34 : 289-295, 1996

      18 Ali-Melkkila T, "Pharmacokinetics and related pharmacodynamics of anticholinergic drugs" 37 : 633-642, 1993

      19 Eddleston M, "Oximes in acute organophosphorus pesticide poisoning: a systematic review of clinical trials" 95 : 275-283, 2002

      20 Buckley NA, "Oximes for acute organophosphate pesticide poisoning" 2 : 005085-, 2011

      21 Bird S, "Organophosphate and carbamate poisoning"

      22 Abedin MJ, "Open-label randomized clinical trial of atropine bolus injection versus incremental boluses plus infusion for organophosphate poisoning in Bangladesh" 8 : 108-117, 2012

      23 Senanayake N, "Neurotoxic effects of organophosphorus insecticides. An intermediate syndrome" 316 : 761-763, 1987

      24 Wiener SW, "Nerve agents: a comprehensive review" 19 : 22-37, 2004

      25 Thiermann H, "Modern strategies in therapy of organophosphate poisoning" 107 : 233-239, 1999

      26 Eddleston M, "Management of severe organophosphorus pesticide poisoning" 6 : 259-, 2002

      27 Roberts DM, "Management of acute organophosphorus pesticide poisoning" 334 : 629-634, 2007

      28 Sevim S, "Late onset polyneuropathy due to organophosphate (DDVP) intoxication" 30 : 75-78, 2003

      29 Sidell FR, "Intramuscular and intravenous administration of small doses of 2-pyridinium aldoxime methochloride to man" 60 : 1224-1228, 1971

      30 Johnson MK, "Evaluation of antidotes for poisoning by organophosphorus pesticides" 12 : 22-37, 2000

      31 Eddleston M, "Early management after self-poisoning with an organophosphorus or carbamate pesticide: a treatment protocol for junior doctors" 8 : 391-397, 2004

      32 Bird SB, "Early death due to severe organophosphate poisoning is a centrally mediated process" 10 : 295-298, 2003

      33 Eddleston M, "Differences between organophosphorus insecticides in human self-poisoning: a prospective cohort study" 366 : 1452-1459, 2005

      34 Dickson EW, "Diazepam inhibits organophosphate-induced central respiratory depression" 10 : 1303-1306, 2003

      35 Pawar KS, "Continuous pralidoxime infusion versus repeated bolus injection to treat organophosphorus pesticide poisoning: a randomised controlled trial" 368 : 2136-2141, 2006

      36 Perera PM, "Comparison of two commonly practiced atropinization regimens in acute organophosphorus and carbamate poisoning, doubling doses vs. ad hoc: a prospective observational study" 27 : 513-518, 2008

      37 Connors NJ, "Comparison of current recommended regimens of atropinization in organophosphate poisoning" 2013

      38 Peter JV, "Clinical profile and outcome of patients hospitalized with dimethyl and diethyl organophosphate poisoning" 48 : 916-923, 2010

      39 Lee MJ, "Clinical characteristics of acute pure organophosphate compounds poisoning: 38 multi-centers survey in South Korea" 5 : 27-35, 2007

      40 Asari Y, "Changes in the hemodynamic state of patients with acute lethal organophosphate poisoning" 46 : 5-9, 2004

      41 Rump S, "Central therapeutic effects of dihydroderivative of pralidoxime (pro-2- PAM) in organophosphate intoxication" 232 : 321-332, 1978

      42 Karakus A, "Cases of organophosphate poisoning treated with highdose of atropine in intensive care unit and the novel treatment approaches" 2012

      43 Lifshitz M, "Carbamate poisoning and oxime treatment in children: a clinical and laboratory study" 93 : 652-655, 1994

      44 Eyer P, "Are we using the right dose?: a tale of mole and gram" 66 : 451-452, 2008

      45 LeBlanc FN, "A severe organophosphate poisoning requiring the use of an atropine drip" 24 : 69-76, 1986

      46 Suh JH, "A case of amitraz insecticide intoxication after ingestion of large amount" 6 : 52-56, 2008

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      학술지 이력

      학술지 이력
      연월일 이력구분 이력상세 등재구분
      2024 평가예정 해외DB학술지평가 신청대상 (해외등재 학술지 평가)
      2021-01-01 평가 등재학술지 선정 (해외등재 학술지 평가) KCI등재
      2020-12-01 평가 등재 탈락 (해외등재 학술지 평가)
      2013-10-01 평가 등재학술지 선정 (기타) KCI등재
      2011-01-01 평가 등재후보학술지 유지 (기타) KCI등재후보
      2007-01-01 평가 SCOPUS 등재 (신규평가) KCI등재후보
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      학술지 인용정보

      학술지 인용정보
      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 0.33 0.33 0.48
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      0.5 0.57 0.815 0.12
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