광노화 병변의 유병률 조사 및 단일성과 다발성 광선각화증 환자들의 특성 비교: 환자 61명에 대한 후향적 연구 = Prevalences of Actinic Skin Lesions and Comparison of Single and Multiple Lesions in Patients with Actinic Keratosis: A Retrospective Study of 61 Patients

다국어 초록 (Multilingual Abstract)

Background: Photoaged skin is characterized by actinic skin lesions such as wrinkling, elastosis, and premalignant and malignant lesions. Actinic keratosis (AK) is one of the most common precancerous lesions, and multiple actinic keratosis lesions are one of the risk factors for skin cancer. Few studies have investigated the prevalences of actinic skin lesions and compared the characteristics of the lesions and the patients with sinle and multiple AK lesions.
Objective: The aim of this study was to evaluate the prevalences of actinic skin lesions and to compare characteristics between single and multiple lesions in Korean patients with AK.
Methods: We retrospectively reviewed the medical records and biopsy specimens of 61 patients.
Results: Frequencies of deep wrinkle, solar elastosis, cutis rhomboidalis nuchae, and senile purpura were higher in the multiple lesions group. The ratio of males to females was 1：3.43 and the mean age was 79 years in the multiple lesions group, both of which were higher than those in the single lesion group (1：1.14, 72 years). The mean duration was longer in the multiple lesions group. Sun protective behavior was more frequent in the single lesion group, and the occupation of farmer was more common in the multiple lesions group. There was no statistically significant clinicopathological difference between the two groups.
Conclusion: This study may improve our understanding of the characteristics of actinic keratosis with both single and multiple lesions. (Korean J Dermatol 2017;55(9):580∼587)

참고문헌 (Reference)

1 김성근, "충청남도 지역에서 진단된 광선 각화증에 대한 임상 및 병리조직학적 고찰" 대한피부과학회 48 (48): 001-007, 2010

2 이승자, "자외선 차단행동과 자외선차단제 사용 실태에 관한 연구 − 연령과 성별 특성을 중심으로 −" 한국미용학회 19 (19): 448-455, 2013

3 이동윤, "광선각화증의 임상 및 조직학적 연구" 대한피부과학회 49 (49): 1-5, 2011

4 김유정, "광선 각화증의 임상 및 조직학적 고찰" 대한피부과학회 43 (43): 211-217, 2005

5 DS Rigel, "The importance of early diagnosis and treatment of actinic keratosis" 68 : S20-S27, 2013

6 Diana CC, "The clinical spectrum of actinic keratosis" 32 : 1016-1024, 1995

7 Marks R, "Spontaneous remission of solar keratoses: the case for conservative management" 115 : 649-655, 1986

8 Marks R, "Solar keratosis" 122 (122): 49-60, 1990

9 MA Weinstock, "Reliability of counting actinic keratoses before and after brief consensus discussion: The VA topical tretinoin chemoprevention (VATTC) trial" 137 : 1055-1058, 2001

10 AA Memon, "Prevalence of solar damage and actinic keratosis in a Merseyside population" 142 : 1154-1159, 2000

11 Valquiria PC, "Prevalence of actinic skin lesions in patients with basal cell carcinoma of the head: a casecontrol study" 58 : 158-196, 2011

12 SC Flohil, "Prevalence of actinic keratosis and its risk factors in the general polulation: The Rotterdam study" 133 : 1971-1978, 2013

13 Theodore R, "Prevalence and awareness of actinic keratosis: Barriers and opportunities" 68 : S2-S9, 2013

14 Marks R, "Malignant transformation of solar keratoses to squamous cell carcinoma" 9 : 795-797, 1988

15 SJ Salasche, "Epidermiology of actinic keratosis and squamous cell carcinoma" 42 : S4-S7, 2000

16 Robert J, "Elderly and sun-affected skin" 47 : 1236-1243, 2001

17 Chang SN, "Clinical and histopathological observations of actinic keratosis in Korea" 35 : 931-939, 1997

18 Cemal B, "Chronic actinic damage of facial skin" 32 : 752-762, 2014

19 Rossi R, "Actinic keratosis" 46 : 895-904, 2007