Adenovirus와 항원 생성에 관한 연구

다국어 초록 (Multilingual Abstract)

Adenoviruses possess complement-fixing antigen which has been separated from infectious virus. It is a subject to determine whether the CF antigen represents a precursor of infectious adenovirus particle or whether the CF antigen is a product formed independently and concomitantly with infectious particle. This report describes the experiments which study the relationship between CF antigen and infectious virus and determine the time of detection of these two properties. In these experiments adenovirus types 1, 4, 5, were employed. Results were as follows. 1. Intracellular CF antigen had eclipse period of 18-21 hrs and intracellular infectious was detected 16-21 hrs after infection of HeLa cells. 2. CF antigen and infectious virus were produced independently and the CF antigen was not a precursor to infectious virus. 3. HeLa cells infected with adenovirus type 4 were capable of continued antigen production despite early development of maximun cytopathogenic effect. 4. The present study with adenovirus types, 1, 4, 5 indicated these viruses have similar growth cha- racteristics.