만성신부전환자에서 공복 및 식후 혈청 Gastrin 치의 변동 = Fasting and Postprandial Serum Gastrin Change in Patients with Chronic Renal Failure만성신부전환자에서 공복 및 식후 혈청 Gastrin 치의 변동

다국어 초록 (Multilingual Abstract)

Chronic renal failure is frequently (11.2-53%) associated with peptic ulcer, but the mechanism has not been elucidated. The kidney has been known to be the site of degradation of gastrin. The gastrin, especially Big Gastrin (G34), is increased in patients with chronic renal failure. This study was undertaken to determine the fasting and postprandial serum gastrin change in patients with chronic renal failure. Serum gastrin levels of the fasting and postprandial 15, 45, 90, and 120 minutes after ingestion of milk were measured by radioimmunoassay in 13 patients with chronic renal failure and in 12 normal control subjects. In normal controls, the serum gastrin levels were significaotly increased at 15 and 45 minutes after ingestion of milk, while in patients with chronic renal failure they were significantly increased at 15, 45, 90 and 120 minutes, The peak gastrin levels were at 45 minutes. The fasting and postprandial serum gastrin responses to milk in patients with chronic renal failure were significantly higher than in normal controls. There was no significant correlation between the fasting serum gastrin level and serum levels of calcium, phosphorus, blood urea nitrogen, creatinine and parathyroid hormone.