복수를 (腹水) 동반한 간경화증에서 (肝鏡化症) 복수내 (腹水內) Albumin 의 전신혈류로 (全身血流) 환류에 (還流) 관한 연구 = Back Flow of Albumin from Ascites to Blood - as a Result of Ascitic Ultrafiltration in Liver Cirrhosis -복수를 (腹水) 동반한 간경화증에서 (肝鏡化症) 복수내 (腹水內) Albumin 의 전신혈류로 (全身血流) 환류에 (還流) 관한 연구

다국어 초록 (Multilingual Abstract)

Ascitic ultrafiltration and intraperitoneal reinfusion therapy for intractable ascites in liver cirrhosis removes ascites fluid rapidly and increases urine output, which is thought as a result of increased effective blood volume by inducing gradual backflow of concentrated ascitic albumin into circulation. To demonstrate a net transfer of ascitic albumin to blood by this therapy in cirrhotic intractable ascitic patient, I-181 labeld human serum albumin was administered intraperitoneally after ascitic ultrafiltration, and thereafter blood samples were chawn serially and radioactivity in these sample were measured. The blood levels of I-131-HSA increased gradually over 48 hours with the peak rate of blood uptake achieved at 6 hour and the peak levels is thought to be achieved at 72 hour considering the rate of uptake. At 48 hour, 6.47% of the isotope administered had appeared in the blood when corrections are made for transfer of labeled albumin into ascites and other extracellular space and degradation of labeled albumin, At 72 hour the precentage of ascitic albumin returned to blood appears to be at least 10% By this studies we can provides the therapeutic basis for ascitic ultrafiltration intraperitoneal reinfusion therapy in intractable ascites.