삼채 뿌리 보충식이가 당뇨 흰쥐의 조직에서 항산화효소 활성도에 미치는 영향 = Effects of Dietary Supplementation with Allium hookeri Root on the Antioxidant Enzyme Activities in Streptozotocin-Induced Diabetic Rats

다국어 초록 (Multilingual Abstract)

This study examined the effects of Allium hookeri (AH) root on the antioxidant defense in streptozotocin (STZ)-induced diabetic rats. Rats were rendered diabetic by STZ (45 mg/kg body weight) administration. The experimental groups were divided into four groups: a normal-control (N-control), STZ-control, STZ-AH 5%, and STZ-AH 10% supplemented groups. The N-control and STZ-control group were fed an AIN-93 diet, and the experimental groups were fed a modified diet containing 5% and 10% of AH root powder for 4 weeks. The activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione S-transferase (GST), and xanthine oxidase (XOD) were measured in the kidney, lung, and brain. The SOD activities in the lung and brain were significantly lower in the STZ-AH 10% group than in the STZ-control group. The activity of CAT in the kidney was significantly higher in the STZ-AH 10% group than in the STZ-control group. The GR activities in the kidney and lung were reduced in STZ-AH 5% and STZ-AH 10% group, respectively. In the kidney, the activity of GPx was significantly higher in the STZ-AH 5% group than in the STZ-control group. Similar results were observed for the lung. The GST activity was significantly lower in the STZ-AH 5% group in the kidney but significantly higher in the STZ-AH 10% group in the lung compared to the STZ-control group. The XOD activities in the kidney and brain were significantly lower in the STZ-AH 10% group than in the STZ-control group. Allium hookeri root contains bioactive compounds that possess important antioxidant properties and protected the kidneys, lung and brain from hyperglycemia damage.

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