운동강도와 지속시간에 따른 트레드밀 운동이 비만 쥐의 심장근 내 항산화에 미치는 영향 = The Effect of Antioxidative Change in Cardiac Muscle of Obesity Rat by Treadmill Exercise with Intensity and Time

다국어 초록 (Multilingual Abstract)

The aims of this study was to observed an effect of antioxidative in cardiac muscle of high fat diet induced obesity rat by treadmill exercise with intensity and time. Thirty-two Sprauge-Dawley rats which were divided into four group. Normal, Control(high fat diet induced obesity rat), Experimental I(high intensity intermittent exercise in high fat diet induced obesity rat), Experimental II(moderate intensity endurance exercise in high fat diet induced obesity rat). The results of this study were as follows: 1. In change of body weight, the outcome of each group significantly difference compared with control. Also, 1 to 3 weeks significantly different compared with pre valu experimental I and II(p<0.001). 2. In change of lipid profile, the outcome of each group significantly difference compared with control(p<0.001). Difference between experimental I and II is not significantly. 3. In change of antioxidative enzymes(SOD, CAT, GPx) in myocardium, there are significant difference between control and experimental II, and also between control and experimental I(p<0.001). 4. In change of antioxidative protein MCR-1, the outcome of each group significantly difference compared with control(p<0.01). Experimental II was most significantly difference than the other group(p<0.001). The above results suggest that treadmill exercise effectively reduced in fat. It would be considered that moderate intensity endurance exercise has an effects on improved antioxidative enzyme in cardiac muscle of high fat diet induced obesity rat.

참고문헌 (Reference)

1 김재우, "중강도 운동과 Quercetin투여가 고지방식이 유도 비만쥐의 심장근 항산화 및 미토콘드리아 생합성 단백질 발현에 미치는 영향" 경북대학교 대학원 2010

2 김승현, "유산소 운동과 흑마늘 섭취가 흰쥐의 혈중지질, 지질과산화 및 항산화 능력에 미치는 영향" 한국생명과학회 21 (21): 1025-1031, 2011

3 방기열, "운동형태에 따른 비만쥐의 지방조직내 항산화 효소 및 염증관련인자의 변화" 전북대학교 교육대학원 2011

4 백경아, "운동 강도에 따른 흰쥐 심장근 조직의 항산화 효소활성과 조직형태학적 변화" 한남대학교 대학원 2002

5 문성숙, "비만관리 운동 프로그램이 비만여성의 신체구성 및 혈중지질에 미치는 영향" 인천대학교 교육대학원 2011

6 Levin B. E., "new obesity-prone, glucose-intolerant rat strain(FDIO)" 285 (285): 1184-1191, 2003

7 Westhoff T. H., "Too old to benefit from sports?: The cardiovascular effects of exercise training in elderly subjects treated for isolated systolic hypertenson" 30 (30): 240-247, 2007

8 Andrade AM, "The effect of physical activity on weight loss is mediated by eating self-regulation" 79 (79): 320-326, 2010

9 Kim HD, "The effect of an exercise program on body composition and physical fitness in obese female college students" 36 (36): 5-14, 2006

10 Ficiciar H., "The Effects of short-term training on platelet functions and total antioxidant capacity in rats" 55 (55): 151-156, 2006

11 Vincent H. K., "Short-term exercise training improves diaphragm antioxidant capacity and endurance" 81 (81): 67-74, 2000

12 Press V., "Physical activity: The evidence of benefit in the prevention of coronary heart disease" 96 (96): 245-251, 2003

13 Carlsohn A., "Physical activity, antioxidant status and protein modification in adolescent athletes" 42 (42): 1131-1139, 2010

14 Farooqi IS, "Partial leptin deficiency and human adiposity" 414 (414): 34-35, 2001

15 Leeuwenburgh C., "Oxidative stress and antioxidants in exercise" 8 (8): 829-838, 2001

16 Husain K., "Oxidative injury due to chronic nitric oxide synthase inhibition in rat: effect of regular exercise on the heart" 1587 (1587): 75-82, 2002

17 Banerjee A. K., "Oxidants, antioxidants and physical exercise" 253 (253): 307-312, 2003

18 Rossner S, "Obesity through the ages of man" 25 (25): 529-533, 2001

19 Bensimhon DR, "Obesity and physical activity: a review" 151 (151): 598-603, 2006

20 Higdon JV, "Obesity and oxidative stress: a direct link to CVD?" 23 (23): 365-367, 2003

21 Sartipy P., "Monocyte chemoattractant protein1 in obesity and insulin resistance" 100 (100): 7265-7270, 2003

22 Carriere A., "Mitochondrial reactive oxygen species control the transcription factor CHOP-10/GADD153 and adipocyte differentiation: a mechanism for hypoxia-dependent effect" 279 (279): 40462-40469, 2004

23 Lin M. T., "Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases" 443 (443): 787-795, 2006

24 Kanda H., "MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance and hepatic steatosis in obesity" 116 (116): 1494-1505, 2006

25 Lira F. S., "Low and moderate, rather than high intensity strength exercise induces benefit regarding plasma lipid profile" 2 (2): 31-37, 2010

26 Durstine J. L., "Lipids, lipoproteins and exercise" 22 (22): 385-398, 2002

27 Kimura N., "Intrinsic oxidative stress causes either two -cell arrest or cell death depending on developmental stage of the embryos from SOD- deficient mice" 16 (16): 441-451, 2010

28 Hill J. O., "International strategies to address obesity" 9 (9): 41-47, 2008

29 Carey A. L., "Interleukin-6 and insulin sensitivity: friend or foe?" 47 (47): 1135-1142, 2004

30 Seifi-Skishahr F., "Influence of aerobic exercise at high and moderate intensities on lipid peroxidation in untrained men" 48 (48): 515-521, 2008

31 Furukawa S., "Increased oxidative stress in obesity and its impact on metabolic syndrome" 114 (114): 1752-1761, 2004

32 Denton J. C., "Improvements in glucose tolerance in obese males with abnormal glucose tolerance following 10 days of aerobic exercise" 38 (38): 885-888, 2004

33 Bejma J., "Free radical generation and oxidative stress with ageing and exercise: differential effects in the myocardium and liver" 169 (169): 343-351, 2000

34 Friedman M., "Feeding tomtoes to hamsters reduces their plasma low density lipoprotein cholesterol and triglycerides" 65 (65): 897-900, 2000

35 Slentz CA, "Exercise, abdominal obesity, skeletal muscle and metabolic risk: evidence for a dose response" 17 (17): S27-S33, 2009

36 Fogarty M. C., "Exercise induced lipid peroxidation: implications for deoxyribonucleic acid damage and systemic free radical generation" 52 (52): 35-42, 2011

37 Thompson P. D., "Exercise and physical activity in the prevertion and treatment of atherosclerotic cardiovascular disease: a statement form the council on clinical cardiogy and the council on nutrition, physical activity and metabolism" 23 (23): 3109-3116, 2003

38 Powers S. K., "Exercise and cardioprotection" 17 (17): 495-502, 2002

39 Irie F, "Enhanced risk for Alzheimer disease in persons with type 2 diabetes and APOE epsilon4: the Cardiovascular Health Study Cognition Study" 65 (65): 89-93, 2008

40 Nakao C., "Effects of swimming trainning on three superoxide dismutase is enzymes in mouse tissues" 88 (88): 649-654, 2000

41 Gollisch K. S. C., "Effects of exercise training on subcutaneous and visceral adipose tissue in normal and high-fat diet-fed rats" 297 (297): 495-504, 2009

42 Shahid S. K., "Effects of exercise on insulin resistance syndrome" 11 (11): 103-109, 2000

43 Mustafa G., "Effects of endurance training and acute exhaustive exercise on antioxidant defence mechanism in rat heart" 143 (143): 239-245, 2006

44 Luciano A, "Effects of different models of physical exercise on oxidative stress markers in mouse liver" 34 (34): 60-65, 2009

45 LaPier T. L., "Effects of aerobic exercise on energy metabolism in the hypertensive rat heart" 81 (81): 1006-1017, 2000

46 Diniz Y. S., "Diets rich in saturated and polyunsaturated fatty acids: metabolic shifting and cardiac health" 20 (20): 230-234, 2004

47 Chen A, "Diet induction of monocyte chemoattractant protein-1 and its impact on obesity" 13 (13): 1311-1320, 2005

48 Brigelius-Flohe R, "Commentary: oxidative stress reconsidered" 4 (4): 161-163, 2009

49 Festa A., "Chronic subclinical inflammation as part of the insulin resistance syndrome: the insulin resistance atherosclerosis study(IRAS)" 102 (102): 42-47, 2000

50 Xu H., "Chronic inflammation in fat plays a crucial role in the development of obesity- related insulin resistance" 112 (112): 1821-1830, 2003

51 Aebi H, "Catalase in method of enzymatic analy" Acade Press 673-684, 1974

52 Selman C., "Antioxidant enzyme activities, lipid peroxidation and DNA oxidative damage the effects of short-term voluntary wheel running" 401 (401): 255-261, 2002

53 Inal M. E., "Antioxidant enzyme activities and malondialdehyde levels related to aging" 305 (305): 75-80, 2001

54 Fasshauer M., "Adiponectin, obesity and cardiovascular disease" 86 (86): 779-784, 2004

55 Kelsey F. W., "Acute exercise and oxidative stress: a 30 year history" 8 (8): 1-25, 2009

56 Watkins L. L., "A. Effects of exercise and weight loss on cardiac risk factors associated with syndrome X" 163 (163): 1889-1895, 2003

57 윤선아, "8주 운동과 일회성 운동이 식욕조절 호르몬 및 혈중지질에 미치는 영향" 인천대학교 대학원 2011