반코마이신 최소억제농도가 침습성 황색포도알균 감염증의 사망에 미치는 영향

다국어 초록 (Multilingual Abstract)

Background: The mortality in patients with Staphylococcus aureus was associated with multiple factors, including resistance to methicillin, inappropriate empirical antibiotics therapy, and reduced susceptibility of S. aureus to vancomycin. Predictors for mortality in patients with S. aureus infection were not fully confirmed. This study was conducted to analyze the clinical and microbiological characteristics related with the 30-day mortality in patients with invasive S. aureus infection.
Patients and Methods: A total of 104 patients with culture-proven S. aureus infection were prospectively collected from September 2009 to June 2010. First S. aureus isolates were collected from patients with invasive S. aureus infection who were admitted to Gyeongsang National University Hospital. Information such as clinical and demographic characteristics, comorbidity, predisposing conditions, severity of illness, and vancomycin minima inhibitory concentration (MIC) was collected.
Results: Seventy-six patients (73%) had methicillin-resistant S. aureus (MRSA) infection and 28 patients (23%) had methicillin-susceptible S. aureus (MSSA) infection. There were no statistical differences between both groups in terms of underlying clinical characteristics. However, patients with MRSA infections were more likely to have the previous antibiotics therapy (P= .026), receipt of urinary catheterization (P= .008), and previous hospital stay (P= .018) than with MSSA infections. Infections caused by S. aureus strains with vancomycin MIC of 2 mg/L were independently associated with higher mortality rate (7.8% vs. 34.4%, P= .002). In multivariate analysis, solid neoplasms (Odd ratio [OR], 12.40; 95% Confidence interval [CI], 1.60-63.42; P= .014) and higher vancomycin MIC of S. aureus (OR, 15.33; 95% CI, 2.02-116.43; P= .008) were significant risk factors for 30-day mortality.
Conclusion: Predictors for mortality of S. aureus infections were higher vancomycin MIC of S. aureus and solid neoplasms. However, methicillin resistance of S. aureus strain was not associated with mortality. Further study is required to establish the factors influencing mortality of S. aureus infections.

목차 (Table of Contents)

• Ⅰ. 서 론 1
• Ⅱ. 연구 대상 및 방법 2
• Ⅲ. 결 과 7
• Ⅳ. 고 찰 12
• Ⅴ. 결 론 16
• ⅤI. 참고 문헌 17