The protective roles of metallothionein(MT) exogeneously adiministered have been examined in the liver and kidney of cadmium(Cd) treated mouse, In Cd treated mouse, cellular damages such as nuclear pyknosis and necrosis were observed, Increased interc...
The protective roles of metallothionein(MT) exogeneously adiministered have been examined in the liver and kidney of cadmium(Cd) treated mouse, In Cd treated mouse, cellular damages such as nuclear pyknosis and necrosis were observed, Increased intercellular spaces and obscure liver lobules were often observed. The extent of damages of liver cells in Cd-MT treated group decreased compared with Cd treated group. And also, MT reactivity of this group was prominent in nuclei and cytoplasm. The enzyme activities of ALT and AST showed less alterations in CchMT treated group. In the case of kidney, protective effects of MT against Cd toxicity were comparatively not clear, In conclusion, these experimental results suggest that metallothionein reduces cellular damages resulted from cadmium in the liver of mouse.