아토피성 기관지천식 환자에서 Pharmacia CAP 시스템으로 측정한 10종의 흡입성 항원에 대한 특이 IgE 성적

다국어 초록 (Multilingual Abstract)

In this study, clinical effectiveness of Pharmacia CAP system for determination of allergen specific IgE was evaluated de- pending on the results of Bencard skin prick tests in 100 atopic and 18 nonatopic asthrnstics. The Pharmacia CAP specific IgE positive rates were higher as the SPT grades were increased: negative (n=623) (17.8%); + (n=81) (34.6%); 2+ (n= 223) (56.5%); 3+ (n=106) (70.8%); and 4+ <= (n=127) 3+ (92.1%), respectively. The overall concordant rate between Bencard SPT and Pharmacia CAP system was 81.7% with range of 70.7-92.1%. The Overall sensitivity of Pharmacia CAP system was 80.7%. The sensitivities for 10 allergens, which ranged from 57.5% to 100 %, were as followed; D.pteronyssinus (96.1 % ), D.farinae (96.7%), cat dander (61.5% ), cockroach (65.2% ), Aspergillus fumigatus (57.1%), ragvreed (62,5%), mugwort (75.0 % ), Meadow fescue (100%), birch (62.4% ), and oak (80.0% ), respectively. Overall specificity of Pharmacia CAP system was 82.2 The specificity of CAP system in nonatopic subjects (n=18, 160 test) was 94.4% which was quite different with the 77.6% of atopic subjects (n=100, 463 test). SPT A/H ratios were significantly correlated with Pharmacia CAP specific IgE concentration (KU/L) in D.pteronyssinus (r =0.520, p<0.001), D.farinae (r=0.490, p< 0.001), A.fumigatus (r=0.315, p<0.01), mugwort (r=0.210, p<0.05), ragweed {r= 0.213, p<0.05), birch (r=0.232, p<0.05), M.fescue (r=0.410, p<0.001). But, in cock- roach (r=0.192, p<0.1), cat, dander and oak pollen, SPT A/H ratios were not correlated with the concentration of specific IgE. These results suggest that Pharmacia CAP system is useful for etiologic evaluation of immediate hypersensitivity and quantitative evaluation of specific IgE in atopic asthma.