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      중추신경 흥분제가 barbiturates의 수면효과에 미치는 영향 = The Influences of Analeptics on Sleeping Time of Barbiturates

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      https://www.riss.kr/link?id=A60251162

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      The present sudies describe the effects of analeptics（caffeine, amphetamine, pent-lenetetrazol）on the duration of barbiturates were determined in rats. Sleeping time of babiturates was determined by the time elapsing between loss and return of the righting reflexes. All drugs were injected intraperitoneally.
      Preliminary experiments indicated that at a dose of 40 ㎎／㎏ either of the two barbiturates produced loss of the righting reflexes without death. This dose was selected for subsequent studies.
      Results are following:
      1. Pretreatment of caffeine, amphetamine and pentylenetetrazol shortened significantly the sleeping time of thiopental sodium but the effects of pentobarbital sodium on sleeping were different according to the does of pretreated drugs（caffeine, amphetamine and pentylentetrazol）.
      2. The sleeping time of pentylentetrazol and thiopental sodium was most prominently shortened by the dose of caffeine 15 ㎎／㎏ in rats.
      3. There was a tendency that the more dose of amphetamine was increased the shorter the duration of sleeping time became.
      4. Pretreated group by 2 ㎎／㎏ pentylentetrazol didn't make significant change on the sleeping effect
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      The present sudies describe the effects of analeptics（caffeine, amphetamine, pent-lenetetrazol）on the duration of barbiturates were determined in rats. Sleeping time of babiturates was determined by the time elapsing between loss and return of the...

      The present sudies describe the effects of analeptics（caffeine, amphetamine, pent-lenetetrazol）on the duration of barbiturates were determined in rats. Sleeping time of babiturates was determined by the time elapsing between loss and return of the righting reflexes. All drugs were injected intraperitoneally.
      Preliminary experiments indicated that at a dose of 40 ㎎／㎏ either of the two barbiturates produced loss of the righting reflexes without death. This dose was selected for subsequent studies.
      Results are following:
      1. Pretreatment of caffeine, amphetamine and pentylenetetrazol shortened significantly the sleeping time of thiopental sodium but the effects of pentobarbital sodium on sleeping were different according to the does of pretreated drugs（caffeine, amphetamine and pentylentetrazol）.
      2. The sleeping time of pentylentetrazol and thiopental sodium was most prominently shortened by the dose of caffeine 15 ㎎／㎏ in rats.
      3. There was a tendency that the more dose of amphetamine was increased the shorter the duration of sleeping time became.
      4. Pretreated group by 2 ㎎／㎏ pentylentetrazol didn't make significant change on the sleeping effect

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