원발성간암의 (原發性肝癌) 임상적고찰 (臨床的) = A Clinical Study of Primary Careinoma of the Liver

다국어 초록 (Multilingual Abstract)

We have presented a clinical study of 711 cases with primary carcinoma of the liver during the period between January 1965 and May 1975. The results are as follows: 1. The highest incidence was seen in the 6th decade and 65.9%o of' total cases belonged to the age group of 5th and 6th decades. There was a significant difference between the sexes; males were 83.Yo and females were 1(I.7Fo. 2. Ma jor symptoms consist of abdominal pain 48. 9%?, anorexia/indigestion (34. 3%), abdom inal di:tension (25. 6%) and paJpable abdominal mass (25. 2Fo). 3. The most frequent physical finding was hepatomega!y (81.g%) and 3aundice (54.0%), abdominal tenderness (51. 6%), ascites (40. 1%) were also frequent. The splenomegaly (lo.zm) was not rare. 4. The commcn associated ahnormal liver function tests were BSP retention (87. 8%), elevated alkaline phosphatase (79. Ofo) and elevated SGOT (76. 3Fo). 5. The serum AFP was positive in 57. 5% of the patients, Those patients with high serum cholesterol level had much higher AFP positive rate than those with low serum cholesterol level. Seventy percent of the patients with mor.e than 00mg% cf serum total cholesterol were AFP positive and there were no AFP negative patients with more than 500 mg% of serum total chol- esterol level. 6. Hepatocellu!ar carcinoma was predominant (93. 4%), while cholangiocarcinoma was rare (6. 2%). Liver cirrhosis was associated with primary carcinoma of the liver in 73. 6Fo and the most frequent form of these was postnecrotic cirrhosis. 7. Various kinds of liver diseases were observed in 0. 5Fo of the patients before onset of primary carcinoma of the liver. Clonorchiasis was the most frequent of these (11.1Fo). 8. Remote metastasis was observed in 17. Oyo and pulmonary metastasis was the most frequent of these (12. 196). 9. There was usually rapidly fatal course in the patients and 9I. 1Fo of the patients had less than 6 months of symptoms before diagnosis. Hepatic coma was the most frequent cause of death and 71. 2% of the patients died within 0 months from onset of symptoms.