cis-Platin이 흰쥐 자궁선상피세포의 미세구조에 미치는 영향 = The Effects of cis-Dichlorodiammineplatinum(Ⅱ) on the Uterine Glandular Epithelial Cells in Albino Rat

다국어 초록 (Multilingual Abstract)

To study the morphological changes of uterine glandular cells by cis-Platin the author has taken this experiment to investigate the effects of cis-Platin on the fine structure of cytoplasmic organelles in the uterine glandular epithelial cells of the albino rat.
The experimental animals were treated with 6.0mg/Kg for chronic toxic effects, and injected with 2.0mg/Kg during 3 weeks for acute toxic effects. After the final administration the animals were sacrificed at the 1st, 3rd day, and 1st, 2nd and the 3rd week. The specimen obtained from the corpus uteri. The ultrathin section (600-800A in thick) were stained uranyl acetate and lead citrate and observed with transmission electron microscope (Hitachi-600).
The results were as follows :
In the glandular epithelial cells treated with cis-Platin, some mitochondria revealing disorganized mitochondrial cristae and double membrane, parts of cisterane of rough endoplamic reticulum showing fragmented and sacculated, and detached membranebound ribosomes, atrophied and degenerated Golgi complex to whorled membranous body are observed, and the number of secondary lysosomes such as multivesicular body, autophagic vacuole and whorled membranous body are much more than that of control group.
It is demonstrated that though cis-Platin may cause degenerative changes in the uterine glandular cells of rats in acute and chronic toxic experiments, these toxic effects are regressed with time.