(R)-케토프로펜과 (S)- 케토프로펜 분리를 위한 유사 이동층 크로마토그래피의 전산모사

다국어 초록 (Multilingual Abstract)

A simulation study for finding purity changes of extract and raffinate as well as the best purity of (S)-ketoprofen in simulated moving bed (SMB) was performed with changing parameters of m2 and m3 from triangle theory. Aspen simulator allowed separation process simulation of (R)- and (S)-ketoprofen in SMB and compared 4-bed SMB and 8-bed SMB based on the same Henry constant and mass transfer coefficient. The 4-bed SMB consisted of 4 columns (200 mm of length, 10 mm of diameter) and the 8-bed SMB constructed by 8 columns (100 mm of length, 10 mm of diameter), and therefore total column length was made the same as 800 mm. Considering purities of both (R)-and (S)-ketoprofen, both 4-bed SMB and 8-bed SMB had the best purity when m2 and m3 were on 12.0 and 13.0 in the center of triangle. Taking only (S)-ketoprofen into account, 4-bed SMB as well as 8-bed SMB had the best purity when m2 and m3 were on 10.9 and 12.6 in the left outside triangle, and their purities were 93.3 % for 4-bed SMB and 96.9 % for 8-bed SMB.

목차 (Table of Contents)

• Abstract
• 1. 서론
• 2. SMB의 이론적 배경
• 3. Aspen chromatography를 이용한 SMB 전산모사
• 4. 전산모사 결과 및 고찰
• 5. 결론
• REFERENCES

참고문헌 (Reference)

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9 김인호, "A Novel Design of Simulated Moving Bed (SMB) Chromatography for Separation of Ketoprofen Enantiomer" 한국생물공학회 9 (9): 285-291, 2004