HbsAg 양성 간질환에 있어서 혈청 IV 형 Collagen - 7S ( 7S domain ) 의 농도 = Serum Collagen Type IV - 7S in HbsAg Positive Liver Disease

다국어 초록 (Multilingual Abstract)

Background: The purpose of this investigation was to determine the usefulness of serum type IV collagen 7S domain in the evaluation of the extent of hepatic fibrosis. We compared the level of serum collagen 7S domain to the degree of collagen type IV staining of hepatic tissue in various liver diseases. Method: We evaluated 70 cases of HBsAg positive patients and 32 cases of normal controls. Serum 7S domains were measured by CGR gammatic 5310 and collagen type IV 7S kit and each hepatic tissue were stained with monoclonal mouse collagen IV (DAKO-COLLAGEN) staining. Result: 1) Compared to 32 normal volunteers (mean±S.D. = 2.8±1.4ng/ml), 7S domain concentrations were moderately elevated in patients with acute viral hepatitis (mean±S.D=5.4±1.8ng/ml; p<0.001) and chronic persistent hepatitis (meankS.D.=5.5±1.4ng/ml; p<0.001), and significantly elevated in chronic active hepatitis (mean+S.D.=8,4±2.3ng/ml; p<0,001) and liver cirrhosis (mean+S.D.=15,1±6.3ng/ml; p<0,001). 2) Compared to patients with acute viral hepatitis, 7S domain concentrations were not elevated in patients with chronic persistent hepatitis but moderately elevated in patients with chronic active hepatitis (p<0.001) and significantly elevated in patients with liver cirrhosis. 3) Compared to patients with chronic active hepatitis, 7S domain contrations were significantly elevated in patients wih liver cirrhosis. 4) The level of serum type IV collagen 75 domains were correlated to the degree of collagen type IV staining in hepatic tissues. Conclusion: These data suggest that 7S domain of collagen type IV serum levels reliably reflect the degree of hepatic fibrosis in patients with chronic liver disease.