쥐의 實驗的 葡萄狀球菌性乳房炎에 關한 硏究 = Experimental Staphylococcal Mastitis in the Rat

다국어 초록 (Multilingual Abstract)

The purpose of the present experiment is to determine the suitability of rat model for the experimental staphylococcal mastitis. A strain of Staphylococcus aureus isolated from a case of bovine mastitis was inoculated through the teat canal into the mammary gland of lactating rats. The rats were removed from their offspring or left with them to allow suckling, as required by the experimental design.
1. No generalized reactions or symptoms of mastitis were observed in all rats.
2. At necropsy, affected glands showed discoloration; abscesses up to 2.5mm in diameter were observed in one group of "lactating" rats inoculated with 10x10?? colony-forming units of staphylococcus.
3. Histologically fat droplets retained within the alveoli were prominent in many sections. Epithelial hyperplasia and slight interalveolar fibrosis were also noted.
4. The number of bacteria recovered from the inoculated mammary gland was smaller than that of bacteria inoculated. The bacteria were more readily recoverable from the mammary glands of "non-lactating" rats than from "lactating" rats.
5. To determine a suitable rat model for the experimental staphylococcal mastitis, further studies should be carried out, using different strains of Staphylococcus aureus and also different strains of rats.