알레르기성 접촉 피부염이 피부의 자극반응에 미치는 영향 = The Effect of An Allergic Contact Dermatitis on the Irritant Response in Guinea Pigs알레르기성 접촉 피부염이 피부의 자극반응에 미치는 영향

다국어 초록 (Multilingual Abstract)

The effect of an allergic contact dermatitis on the irritant was studied using DNCB(2. 5% in acetone) as the sensitizing agent and sodium lauryl sulfate of various concentrations (0. 5, 1. 0, 2. 0% in Vaseline) as the irritant. Three groups of 30 albino Hartley strain female guinea pigs weighing between 350 g and 500 g were used. The results were as follows: 1. The animals which were sensitized with DNCB were shown to be significantly(p<0.05) more irritable than control animals. 2. The animals which were sensitized and challenged with DNCB were shown to be significantly(p<0. 05) more irritable than control and sensitized animals. These data suggest that allergic contact sensitivity as well as allergic contact dermatitis lower the threshold to a nonspecific irritant in guinea pigs, which may explain a mechanism of 'angry back syndrome.