家兎 側腦室內 Physostigmine의 利尿效果에 關한 硏究 = Studies on the Diuretic Effects of Intraventricular Physostigmine in the Rabbit

다국어 초록 (Multilingual Abstract)

Effect of intraventricular physostigmine on the renal function of rabbits was investigated. The results were as follows.
1. Intraventricular Physostigmine (below 0.3㎍ per rabbit) did not affect the renal function but induced diuretic action in does ranging 10㎍ to 100㎍ per rabbit, exhibited a rough dose-response relationship, and increased renal plasma flow, glomerular filtration rate, urinary excretion of sodium and potassium, concomitant with increased urine flow. On the other hand, intraventricular physostigmine did not influence to filtration fraction and reabsorption of sodium and potassium.
2. Correlation coefficient among the increased urine flow, renal plasma flow and glomerular filtration rate was statistically significant.
3. Intravenous physostigmine (100㎍) did not affect the renal function.
4. Parameters of renal function increased by intraventricular physostigmine were inhibited by intravenous atropine (2mg/kg) or bilateral vagotomr.
These results suggest that the diuretic effects of intraventricular physostigmine in rabbit is mainly due to hemodynamic changes by centrally induced cholinergic mechanism on the kidney.