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      KCI등재 SCOPUS SCIE

      The Effects of Nitroglycerin on the Contraction of Rat Uterine Smooth Muscle

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      https://www.riss.kr/link?id=A104327881

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      다국어 초록 (Multilingual Abstract)

      Background: It has been reported that nitroglycerin relaxes not only vascular smooth muscle but also uterine smooth muscle. The aim of the present study was to investigate the effect of nitroglycerin on rat uterine contractile activity in vitro. The effects of nitroglycerin on myometrial spontaneous activity and oxytocin-induced contractions were also observed.
      Methods: Uterine smooth muscle tissues were obtained from non-pregnant female rats (n = 21). The uterine segments were mounted in tissue baths. After spontaneous or oxytocin-induced activity had been accomplished, nitroglycerin in various concentrations was added to the bath and the effects were continuously registered.
      Results: Nitroglycerin induced a dose-dependent inhibition of spontaneous as well as oxytocin-induced myometrial contractile activity. Complete muscular relaxation on spontaneous contractility was obtained at a concentration of 50μg/ml. Complete muscular relaxation on oxytocin-induced contractility was obtained at a concentration of 75μg/ml.
      Conclusions: Nitroglycerin inhibited the uterine contractile response to exogenous oxytocin as well as spontaneous in the estrous rat. (Korean J Anesthesiol 2006; 50: S 57~60)
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      Background: It has been reported that nitroglycerin relaxes not only vascular smooth muscle but also uterine smooth muscle. The aim of the present study was to investigate the effect of nitroglycerin on rat uterine contractile activity in vitro. Th...

      Background: It has been reported that nitroglycerin relaxes not only vascular smooth muscle but also uterine smooth muscle. The aim of the present study was to investigate the effect of nitroglycerin on rat uterine contractile activity in vitro. The effects of nitroglycerin on myometrial spontaneous activity and oxytocin-induced contractions were also observed.
      Methods: Uterine smooth muscle tissues were obtained from non-pregnant female rats (n = 21). The uterine segments were mounted in tissue baths. After spontaneous or oxytocin-induced activity had been accomplished, nitroglycerin in various concentrations was added to the bath and the effects were continuously registered.
      Results: Nitroglycerin induced a dose-dependent inhibition of spontaneous as well as oxytocin-induced myometrial contractile activity. Complete muscular relaxation on spontaneous contractility was obtained at a concentration of 50μg/ml. Complete muscular relaxation on oxytocin-induced contractility was obtained at a concentration of 75μg/ml.
      Conclusions: Nitroglycerin inhibited the uterine contractile response to exogenous oxytocin as well as spontaneous in the estrous rat. (Korean J Anesthesiol 2006; 50: S 57~60)

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      참고문헌 (Reference)

      1 "Treatment of HELLP syndrome with nitric oxide donor" 345 : 124-125, 1995

      2 "The use of nitrates in cardiac anesthesia" 97 : -5, 1992

      3 "Role of intravenous nitroglycerin in the treatment of severe pregnancy-induced hypertension complicated by pulmonary edema" 154 : 91-3, 1986

      4 "Placental tissue enhances uterine relaxation by nitroglycerin" 86 : 304-304, 1998

      5 "Intravenous nitroglycerin for uterine relaxation in the postpartum patient with retained placenta" 71 : 172-3, 1989

      6 "Intravenous nitroglycerin for uterine inversion" 4 : 487-8, 1992

      7 "Intravenous nitroglycerin as a tocolytic agent for intrapartum external cephalic version" 83 : 656-, 1993

      8 "Intravenous nitroglycerin aids manual extraction of retained placenta" 73 : 787-, 1990

      9 "Inhibition of nitric oxide synthesis in rats during pregnancy produces signs similar to those of preeclampsia" 169 : 1316-20, 1993

      10 "Hour glass contraction of the uterus treated with nitrite of amyl" 1 : 377-, 1881

      1 "Treatment of HELLP syndrome with nitric oxide donor" 345 : 124-125, 1995

      2 "The use of nitrates in cardiac anesthesia" 97 : -5, 1992

      3 "Role of intravenous nitroglycerin in the treatment of severe pregnancy-induced hypertension complicated by pulmonary edema" 154 : 91-3, 1986

      4 "Placental tissue enhances uterine relaxation by nitroglycerin" 86 : 304-304, 1998

      5 "Intravenous nitroglycerin for uterine relaxation in the postpartum patient with retained placenta" 71 : 172-3, 1989

      6 "Intravenous nitroglycerin for uterine inversion" 4 : 487-8, 1992

      7 "Intravenous nitroglycerin as a tocolytic agent for intrapartum external cephalic version" 83 : 656-, 1993

      8 "Intravenous nitroglycerin aids manual extraction of retained placenta" 73 : 787-, 1990

      9 "Inhibition of nitric oxide synthesis in rats during pregnancy produces signs similar to those of preeclampsia" 169 : 1316-20, 1993

      10 "Hour glass contraction of the uterus treated with nitrite of amyl" 1 : 377-, 1881

      11 "Hemodynamic effects of nitroglycerin and long-acting nitrates" 110 : 216-24, 1985

      12 "Cytosolic-free calcium transients in cultured vascular smooth muscle cells:microfluorometric measurements" 229 : 553-6, 1985

      13 "Cyclic guanosine monophosphate as a mediator of vasodilation" 78 : 1-5, 1986

      14 "Comparison of intravenous magnesium sulfate and nitroglycerin for preterm labor [abstract]." 174 : 307-, 1996

      15 "Cardiac anesthesia" Philadelphia,WB Saunders 451-517, 1987

      16 "Biological actions and properties of endothelium- derived nitric oxide formed and released from artery and vein" 65 : 1-21, 1989

      17 "Antepartum uterine relaxation with nitroglycerin at cesarean delivery" 39 : 166-9, 1992

      18 "Actions of the nitrates on the peripheral circulation and myocardial oxygen consumption:significance in the relief of angina pectoris" 59 : 296-305, 1971

      19 "A comparison of the effects of various smooth muscle relaxants on the electrical and mechanical activity of rat uterus" 168 : 21-30, 1969

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      2007-01-01 평가 등재 1차 FAIL (등재유지) KCI등재
      2004-01-01 평가 등재학술지 선정 (등재후보2차) KCI등재
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      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 0.09 0.09 0.1
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